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Full-Text Articles in Physical Sciences and Mathematics
Synthesis, Structural Determination, And Biological Activity Of New 7-Hydroxy-3-Pyrazolyl-4h-Chromen- 4-Ones And Their O-\Beta-D-Glucosides, Kishor Hatzade, Vijay Taile, Pravin Gaidhane, Vishwas Ingle
Synthesis, Structural Determination, And Biological Activity Of New 7-Hydroxy-3-Pyrazolyl-4h-Chromen- 4-Ones And Their O-\Beta-D-Glucosides, Kishor Hatzade, Vijay Taile, Pravin Gaidhane, Vishwas Ingle
Turkish Journal of Chemistry
A convenient route to synthesize some new medicinally important 7-hydroxy-3-pyrazolyl chromones (3a-i) is described. The interaction of 7-hydroxy-3-formyl chromone (1) with various substituted acetophenones and further cyclization with hydrazine hydrate in an aprotic solvent followed by condensation with 2, 3, 4, 6-tetra-o-acetyl-\alpha-dglucopyranosyl bromide afforded 2, 3, 4, 6-tetra-o-acetyl-\beta-d-glucopyranosyloxy-3-(3-aryl-1H-pyrazol-5- yl)-4H-chromen-4-ones (4a-i). Later deacetylation with anhydrous zinc acetate in methanol gave 7-o-\beta-d-glucopyranosyloxy-3-(3-aryl- 1H-pyrazol-5-yl)-4H-chromen-4-ones (5a-i). These compounds were evaluated for their in vitro antimicrobial and anti-oxidant activity. The structures of these newly synthesized o-glucosides were established by IR, NMR, mass spectra, elemental analysis, and chemical analysis.
Heterocyclic Synthesis Using Nitrilimines: Part 14. Synthesis Of New Pyrazole Derivatives, Hany Dalloul
Heterocyclic Synthesis Using Nitrilimines: Part 14. Synthesis Of New Pyrazole Derivatives, Hany Dalloul
Turkish Journal of Chemistry
A new series of 1,3,4,5-tetrasubstituted pyrazoles have been synthesized by the 1,3-dipolar cycloaddition of suitable nitrilimines to 3-propylidene and 3-benzylidene-phthalide. Both analytical and spectroscopic data of all the synthesized compounds are in full agreement with the proposed structures.