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Full-Text Articles in Physical Sciences and Mathematics
The Identification Of Amino Acids By Interpretation Of Titration Curves: An Undergraduate Experiment For Biochemistry, Cassidy M. Dobson, Nathan S. Winter
The Identification Of Amino Acids By Interpretation Of Titration Curves: An Undergraduate Experiment For Biochemistry, Cassidy M. Dobson, Nathan S. Winter
Chemistry Faculty Publications
Undergraduate biochemistry students should have great familiarity with titration curves. These curves allow the prediction of protonation states, charges, and isoelectric points. Here we describe an experiment in which students identify four amino acids based on their titration behavior. Students make solutions of each unknown amino acid and monitor the change in pH upon adding aliquots of a strong base. They identify the amino acids based on the shapes of the curves. They annotate the plots with isoelectric points, pKas, buffering regions and the structures of the amino acids.
Design And Synthesis Of A Novel Alpha-Methylene Lactone Chemotherapeutic Agent, Mark F. Mechelke, Jason T. Brethorst, Carina Crookston, Courthney Klinkhammer, Brittany N. Miller, Curtis Payne, Makenzie Pillsbury, Christina R. Ringsmuth, Moriah Traut
Design And Synthesis Of A Novel Alpha-Methylene Lactone Chemotherapeutic Agent, Mark F. Mechelke, Jason T. Brethorst, Carina Crookston, Courthney Klinkhammer, Brittany N. Miller, Curtis Payne, Makenzie Pillsbury, Christina R. Ringsmuth, Moriah Traut
Chemistry Faculty Publications
Goniothalamin, a natural product isolated from the dried stem bark of Malaysian plants of the genus Goniothalamus, has been shown to induce apoptosis in cancer cells. The bioactivity of this molecule is though to be due to its ability to react with thiols. One mechanism involves its reaction with glutathione, a natural antioxidant found in all cells. Using a four step synthetic sequence, a novel gamma-lactone analogue of goniothalamin has been prepared that replaces the endocylic double bond in goniothalamin's lactone core with an exocyclic double bond. It is anticipated that this alteration will allow the compound to react …