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Physical Sciences and Mathematics Commons™
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Full-Text Articles in Physical Sciences and Mathematics
Visualising Dna: Footprinting And 1-2d Gels, Adam Urbach, Michael Waring
Visualising Dna: Footprinting And 1-2d Gels, Adam Urbach, Michael Waring
Adam R Urbach
The study of molecular recognition of DNA by natural and synthetic ligands has made enormous progress due in large part to the discovery and development of methods for separating DNA fragments by gel electrophoresis in one and two dimensions, and for characterizing DNA–ligand complexes by footprinting techniques.
Dna Complexes: Durable Binders, Adam Urbach
Dna Complexes: Durable Binders, Adam Urbach
Adam R Urbach
The ability to program molecules to bind to specific sequences of DNA with high fidelity and stability is an important goal of chemical biology. Such molecules can compete with transcription-factor proteins and thus modulate the transcription of genes. They are therefore promising for both elucidating the complex regulation of mammalian gene expression, and developing pharmaceuticals and medical diagnostics targeted to genetic abberations. Writing in Nature Chemistry, Brent Iverson and co-workers have now described the excellent sequence specificity and unusual binding kinetics of a stable DNA–ligand complex, which exhibits a half-life of 16 days.