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Full-Text Articles in Physical Sciences and Mathematics
Dna Complexes: Durable Binders, Adam Urbach
Dna Complexes: Durable Binders, Adam Urbach
Adam R Urbach
The ability to program molecules to bind to specific sequences of DNA with high fidelity and stability is an important goal of chemical biology. Such molecules can compete with transcription-factor proteins and thus modulate the transcription of genes. They are therefore promising for both elucidating the complex regulation of mammalian gene expression, and developing pharmaceuticals and medical diagnostics targeted to genetic abberations. Writing in Nature Chemistry, Brent Iverson and co-workers have now described the excellent sequence specificity and unusual binding kinetics of a stable DNA–ligand complex, which exhibits a half-life of 16 days.
A Cucurbit[8]Uril Sponge, Vijayakumar Ramalingam, Sharon Kwee, Lisa Ryno, Adam Urbach
A Cucurbit[8]Uril Sponge, Vijayakumar Ramalingam, Sharon Kwee, Lisa Ryno, Adam Urbach
Adam R Urbach
This paper describes a convenient approach to quantitative removal of the synthetic host cucurbit[8]uril (Q8) from aqueous mixtures using a sepharose resin coated in memantine groups to selectively sequester Q8 in the presence of competing hosts and guests. The “Q8 sponge” can separate Q8 from Q6 and reverse the Q8-mediated dimerization of peptides.
Cucurbit[8]Uril Rotaxanes, Vijayakumar Ramalingam, Adam Urbach
Cucurbit[8]Uril Rotaxanes, Vijayakumar Ramalingam, Adam Urbach
Adam R Urbach
The synthesis of [2]rotaxanes, each comprising a viologen core threaded through a cucurbit[8]uril (Q8, Figure 1) macrocycle and stoppered by tetraphenylmethane groups, and their binding to second guests as inclusion complexes in organic and aqueous media are described. Stoppering was observed to have little effect on binding. Chemical modification of the threaded guest was used to control solubility and binding characteristics, thus demonstrating a novel approach to making artificial receptors with readily modifiable properties.