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Pro- And Antioxidant Activity Of Selenomethionine: Preventative Measures Against Metal-Mediated Dna Oxidation, Austin Mroz
Pro- And Antioxidant Activity Of Selenomethionine: Preventative Measures Against Metal-Mediated Dna Oxidation, Austin Mroz
Graduate Theses - Chemistry and Biochemistry
DNA damage by reactive oxygen species (ROS) has been linked to several diseases.
Antioxidants are one method of combating the effects of ROS; selenium-containing antioxidants have shown promise in alleviating in vitro DNA damage. This study aims toelucidate the effects of selenomethionine (SeMet) on DNA damage mediated by Cu(II),Fe(II), or Cr(III) metal ions. HPLC analysis was used to probe the oxidative effects of SeMet by quantifying the oxidative damage marker, 8-hydroxy-2’-deoxyguanosine. Prior literature indicates that the antioxidant activity of SeMet is potentially concentration dependent; however, HPLC results in this study indicate a metal-ion dependency. In order to better understand the …