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Articles 1 - 13 of 13
Full-Text Articles in Physical Sciences and Mathematics
Modifying The Aspect Survey To Support The Validity Of Student Perception Data From Different Active Learning Environments, Nicole Naibert, Erin E. Shortlidge, Jack Barbera
Modifying The Aspect Survey To Support The Validity Of Student Perception Data From Different Active Learning Environments, Nicole Naibert, Erin E. Shortlidge, Jack Barbera
Chemistry Faculty Publications and Presentations
Measuring students’ perceptions of active learning activities may provide valuable insight into their engagement and subsequent performance outcomes. A recently published measure, the Assessing Student Engagement in Class Tool (ASPECT), was developed to assess student perceptions of various active learning environments. As such, we sought to use this measure in our courses to assess the students’ perceptions of different active learning environments. Initial results analyzed with confirmatory factor analysis (CFA) indicated that the ASPECT did not function as expected in our active learning environments. Therefore, before administration within an introductory biology course that incorporated two types of active learning strategies, …
Conserved And Divergent Features Of Neuronal Camkii Holoenzyme Structure, Function, And Highorder Assembly, Olivia R. Buonarati, Adam P. Miller, Steven J. Coultrap, K. Ulrich Bayer, Steve L. Reichow
Conserved And Divergent Features Of Neuronal Camkii Holoenzyme Structure, Function, And Highorder Assembly, Olivia R. Buonarati, Adam P. Miller, Steven J. Coultrap, K. Ulrich Bayer, Steve L. Reichow
Chemistry Faculty Publications and Presentations
Neuronal CaMKII holoenzymes (a and b isoforms) enable molecular signal computation underlying learning and memory but also mediate excitotoxic neuronal death. Here, we provide a comparative analysis of these signaling devices, using single-particle electron microscopy (EM) in combination with biochemical and live cell imaging studies. In the basal state, both isoforms assemble mainly as 12-mers (but also 14-mers and even 16-mers for the b isoform). CaMKIIa and b isoforms adopt an ensemble of extended activatable states (with average radius of 12.6 versus 16.8 nm, respectively), characterized by multiple transient intra- and interholoenzyme interactions associated with distinct functional properties. The …
Molecular Mechanisms Underlying Enhanced Hemichannel Function Of A Cataract-Associated Cx50 Mutant, Jun-Jie Tong, Umair Khan, Bassam George Haddad, Peter J. Minogue, Eric C. Beyer, Vivian M. Berthoud, Steve L. Reichow, Lisa Ebihra
Molecular Mechanisms Underlying Enhanced Hemichannel Function Of A Cataract-Associated Cx50 Mutant, Jun-Jie Tong, Umair Khan, Bassam George Haddad, Peter J. Minogue, Eric C. Beyer, Vivian M. Berthoud, Steve L. Reichow, Lisa Ebihra
Chemistry Faculty Publications and Presentations
Connexin-50 (Cx50) is among the most frequently mutated genes associated with congenital cataracts. Although most of these disease-linked variants cause loss of function because of misfolding or aberrant trafficking, others directly alter channel properties. The mechanistic bases for such functional defects are mostly unknown. We investigated the functional and structural properties of a cataract-linked mutant, Cx50T39R (T39R), in the Xenopus oocyte system. T39R exhibited greatly enhanced hemichannel currents with altered voltage-gating properties compared to Cx50 and induced cell death. Coexpression of mutant T39R with wild-type Cx50 (to mimic the heterozygous state) resulted in hemichannel currents whose properties were indistinguishable from …
Understanding Hyperporphyrin Spectra: Tddft Calculations On Diprotonated Tetrakis(-Aminophenyl)Porphyrin., Jeanet Conradie, Carl C. Wamser, Abhik Ghosh
Understanding Hyperporphyrin Spectra: Tddft Calculations On Diprotonated Tetrakis(-Aminophenyl)Porphyrin., Jeanet Conradie, Carl C. Wamser, Abhik Ghosh
Chemistry Faculty Publications and Presentations
A detailed TDDFT study (with all-electron STO-TZ2P basis sets and the COSMO solvation model) has been carried out on the effect of diprotonation on the UV-vis-NIR spectra of free-base tetraphenylporphyrin and tetrakis(-aminophenyl)porphyrin. The diprotonated forms have been modeled as their bis-formate complexes, i.e., as so-called porphyrin diacids. The dramatic redshift of the Q-band of the TAPP diacid has been explained in terms of an elevated "a" HOMO and lowered LUMOs, both reflecting infusion of aminophenyl character into the otherwise classic Gouterman-type frontier MOs. The exercise has also yielded valuable information on the performance of different exchange-correlation functionals. Thus, the hybrid …
E-Cigarette Fluids And Aerosol Residues Cause Oxidative Stress And An Inflammatory Response In Human Keratinocytes And 3d Skin Models., Careen Khachatoorian, Wentai Luo, Kevin J. Mcwhirter, James F. Pankow, Prue Talbot
E-Cigarette Fluids And Aerosol Residues Cause Oxidative Stress And An Inflammatory Response In Human Keratinocytes And 3d Skin Models., Careen Khachatoorian, Wentai Luo, Kevin J. Mcwhirter, James F. Pankow, Prue Talbot
Chemistry Faculty Publications and Presentations
Our goal was to evaluate the effects of EC refill fluids and EC exhaled aerosol residue (ECEAR) on cultured human keratinocytes and MatTek EpiDerm™, a 3D air liquid interface human skin model. Quantification of flavor chemicals and nicotine in Dewberry Cream and Churrios refill fluids was done using GC-MS. The dominant flavor chemicals were maltol, ethyl maltol, vanillin, ethyl vanillin, benzyl alcohol, and furaneol. Cytotoxicity was determined with the MTT and LDH assays, and inflammatory markers were quantified with ELISAs. Churrios was cytotoxic to keratinocytes in the MTT assay, and both fluids induced ROS production in the medium (ROS-Glo™) and …
Enrolling Reactive Oxygen Species In Photon-To-Chemical Energy Conversion: Fundamentals, Technological Advances, And Applications, Irving D. Rettig, Theresa M. Mccormick
Enrolling Reactive Oxygen Species In Photon-To-Chemical Energy Conversion: Fundamentals, Technological Advances, And Applications, Irving D. Rettig, Theresa M. Mccormick
Chemistry Faculty Publications and Presentations
In theory, oxygen (O2) is an ideal chemical reagent because of its high relative abundance and negligible environmental toxicity. In practice however, by the nature of its ground state electronic configuration, many chemical reactions involving O2 are spin forbidden which dramatically decreases its reactivity and thus its utility in applications. More reactive forms of O2 can be achieved by changing its electronic configuration through the use of photochemical and photophysical methods. This review highlights the roll of photon-to-chemical energy conversion in two of these reactive oxygen species (ROS): superoxide (O2−) and singlet oxygen (1O2), which can be accessed through a …
Efficacy Of Ryr2 Inhibitor El20 In Induced Pluripotent Stem Cell-Derived Cardiomyocytes From A Patient With Catecholaminergic Polymorphic Ventricular Tachycardia., Tarah A. Word, Ann P. Quick, Christina Y. Miyake, Mayra K. Shak, Xiaolu Pan, Jean J. Kim, Hugh D. Allen, Martha Sibrian-Vazquez, Robert M. Strongin, Andrew P. Landstrom, Xander H T Wehrens
Efficacy Of Ryr2 Inhibitor El20 In Induced Pluripotent Stem Cell-Derived Cardiomyocytes From A Patient With Catecholaminergic Polymorphic Ventricular Tachycardia., Tarah A. Word, Ann P. Quick, Christina Y. Miyake, Mayra K. Shak, Xiaolu Pan, Jean J. Kim, Hugh D. Allen, Martha Sibrian-Vazquez, Robert M. Strongin, Andrew P. Landstrom, Xander H T Wehrens
Chemistry Faculty Publications and Presentations
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited cardiac arrhythmia syndrome that often leads to sudden cardiac death. The most common form of CPVT is caused by autosomal-dominant variants in the cardiac ryanodine receptor type-2 (RYR2) gene. Mutations in RYR2 promote calcium (Ca ) leak from the sarcoplasmic reticulum (SR), triggering lethal arrhythmias. Recently, it was demonstrated that tetracaine derivative EL20 specifically inhibits mutant RyR2, normalizes Ca handling and suppresses arrhythmias in a CPVT mouse model. The objective of this study was to determine whether EL20 normalizes SR Ca handling and arrhythmic events in induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) …
Total Synthesis And Antimalarial Activity Of 2-(-Hydroxybenzyl)-Prodigiosins, Isoheptylprodigiosin, And Geometric Isomers Of Tambjamine Myp1 Isolated From Marine Bacteria., Papireddy Kancharla, Yuexin Li, Monish Yeluguri, Rozalia A. Dodean, Kevin A. Reynolds, Jane X. Kelly
Total Synthesis And Antimalarial Activity Of 2-(-Hydroxybenzyl)-Prodigiosins, Isoheptylprodigiosin, And Geometric Isomers Of Tambjamine Myp1 Isolated From Marine Bacteria., Papireddy Kancharla, Yuexin Li, Monish Yeluguri, Rozalia A. Dodean, Kevin A. Reynolds, Jane X. Kelly
Chemistry Faculty Publications and Presentations
Highly efficient and straightforward synthetic routes toward the first total synthesis of 2-(-hydroxybenzyl)-prodigiosins (-), isoheptylprodigiosin (), and geometric isomers of tambjamine MYP1 ((/)-) have been developed. The crucial steps involved in these synthetic routes are the construction of methoxy-bipyrrole-carboxaldehydes (MBCs) and a 20-membered macrocyclic core and a regioselective demethylation of MBC analogues. These new synthetic routes enabled us to generate several natural prodiginines - in larger quantity. All of the synthesized natural products exhibited potent asexual blood-stage antiplasmodial activity at low nanomolar concentrations against a panel of parasites, with a great therapeutic index. Notably, prodiginines and - provided curative in …
Supporting Biomedical Research Training For Historically Underrepresented Undergraduates Using Interprofessional, Nonformal Education Structures, Lisa K. Marriott, Aaron Raz Link, Roberto P. Anitori, Ernest A. Blackwell, Andrea Blas, Jennifer Brock, Tracey K. Burke, Julia A. Burrows, Alexis P. Cabrera, Derek Helsham, Lorna B. Liban, Marilyn R. Mackiewicz, Mika Maruyama, Kathryn C.A. Milligan-Myhre, Perry J.C. Panelinan, Margaret Hattori-Uchima, Russell Reed, Ben E. Simon, Beylul Solomon, Alma M.O. Trinidad, Letisha R. Wyatt, Alonso Delgado Covarrubias, Adrienne Zell, Thomas E. Keller, Cynthia Morris, Carlos J. Crespo
Supporting Biomedical Research Training For Historically Underrepresented Undergraduates Using Interprofessional, Nonformal Education Structures, Lisa K. Marriott, Aaron Raz Link, Roberto P. Anitori, Ernest A. Blackwell, Andrea Blas, Jennifer Brock, Tracey K. Burke, Julia A. Burrows, Alexis P. Cabrera, Derek Helsham, Lorna B. Liban, Marilyn R. Mackiewicz, Mika Maruyama, Kathryn C.A. Milligan-Myhre, Perry J.C. Panelinan, Margaret Hattori-Uchima, Russell Reed, Ben E. Simon, Beylul Solomon, Alma M.O. Trinidad, Letisha R. Wyatt, Alonso Delgado Covarrubias, Adrienne Zell, Thomas E. Keller, Cynthia Morris, Carlos J. Crespo
Chemistry Faculty Publications and Presentations
Research experience provides critical training for new biomedical research scientists. Students from underrepresented populations studying science, technology, engineering, and mathematics (STEM) are increasingly recruited into research pathways to diversify STEM fields. However, support structures outside of research settings designed to help these students navigate biomedical research pathways are not always available; nor are program support components outside the context of laboratory technical skills training and formal mentorship well understood. This study leveraged a multi-institutional research training program, Enhancing Cross-Disciplinary Infrastructure and Training at Oregon (EXITO), to explore how nine institutions designed a new curricular structure (Enrichment) to meet a common …
Anti-Inflammatory And Immunomodulatory Properties Of Fermsented Plant Food, Roghayeh Shahbazi, Farzaneh Sharifzad, Rana Bagheri, Nawal Alsadi, Hamed Yasavoli-Sharahi, Chantal Matar
Anti-Inflammatory And Immunomodulatory Properties Of Fermsented Plant Food, Roghayeh Shahbazi, Farzaneh Sharifzad, Rana Bagheri, Nawal Alsadi, Hamed Yasavoli-Sharahi, Chantal Matar
Chemistry Faculty Publications and Presentations
Fermented plant foods are gaining wide interest worldwide as healthy foods due to their unique sensory features and their health-promoting potentials, such as antiobesity, antidiabetic, antihypertensive, and anticarcinogenic activities. Many fermented foods are a rich source of nutrients, phytochemicals, bioactive compounds, and probiotic microbes. The excellent biological activities of these functional foods, such as anti-inflammatory and immunomodulatory functions, are widely attributable to their high antioxidant content and lactic acid-producing bacteria (LAB). LAB contribute to the maintenance of a healthy gut microbiota composition and improvement of local and systemic immunity. Besides, antioxidant compounds are involved in several functional properties of fermented …
Fluorogenic Probes For Thioredoxin Reductase Activity, Tendai J. Mafireyi, Jorge O. Escobedo, Robert Strongin
Fluorogenic Probes For Thioredoxin Reductase Activity, Tendai J. Mafireyi, Jorge O. Escobedo, Robert Strongin
Chemistry Faculty Publications and Presentations
The thioredoxin system is vital in maintaining the cellular redox state and is implicated in various cancers and other diseases. It comprises of thioredoxin reductase, thioredoxin and NADPH. Various methods have been developed for the detection and quantification of the thioredoxin reductase enzyme. Most of these methods suffer the shortfall of poor specificity, hence there is need to develop more robust and specific techniques. Recently, there has been an increased interest in fluorescent probes that can target thioredoxin reductase. This review highlights the progress in the synthesis and application of the different fluorescent probes that have been employed for this …
Multi-Institutional Study Of Self-Efficacy Within Flipped Chemistry Courses, Nicole Naibert, Kerry D. Duck, Michael M. Phillips, Jack Barbera
Multi-Institutional Study Of Self-Efficacy Within Flipped Chemistry Courses, Nicole Naibert, Kerry D. Duck, Michael M. Phillips, Jack Barbera
Chemistry Faculty Publications and Presentations
Active learning environments have been shown to be beneficial for student learning; however, including such activities can be limited by the class time available. One method that can provide more opportunities for active learning during face-to-face class time is the flipped learning approach. However, studies on the impacts of flipped learning environments on student motivation are limited. Therefore, in this multi-institutional study, general chemistry students enrolled in flipped courses at three institutions responded to measures of self-efficacy and self-regulatory strategies. The results from these measures were used to evaluate how students’ academic self-efficacy (ASE) and chemistry self-efficacy (CSE) changed over …
From Ideas To Items: A Primer On The Development Of Ordered Multiple-Choice Items For Investigating The Progression Of Learning In Higher Education Stem, Katherine Lazenby, Morgan E. Balabanoff, Nicole M. Becker, Alena Moon, Jack Barbera
From Ideas To Items: A Primer On The Development Of Ordered Multiple-Choice Items For Investigating The Progression Of Learning In Higher Education Stem, Katherine Lazenby, Morgan E. Balabanoff, Nicole M. Becker, Alena Moon, Jack Barbera
Chemistry Faculty Publications and Presentations
Identifying effective methods of assessment and developing robust assessments are key areas of research in chemistry education. This research is needed to evaluate instructional innovations and curricular reform. In this primer, we advocate for the use of a type of assessment, ordered multiple-choice (OMC), across postsecondary chemistry. OMC assessments are grounded in a developmental perspective, which treats students’ knowledge as developing in sophistication over time. This is in contrast to a dichotomous perspective, which asserts that students’ knowledge is either aligned or misaligned with scientifically accepted knowledge. By drawing on a developmental perspective, OMC assessments offer insights into student understanding …