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Physical Sciences and Mathematics Commons™
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Full-Text Articles in Physical Sciences and Mathematics
Toward The Design Of Mr Agents For Imaging Β-Cell Function, Mark Woods, Shanrong Zhang, A. Dean Sherry
Toward The Design Of Mr Agents For Imaging Β-Cell Function, Mark Woods, Shanrong Zhang, A. Dean Sherry
Chemistry Faculty Publications and Presentations
The chemistry of Gd3+-based MRI agents has advanced considerably during the past decade toward agents with higher relaxivity and agents that respond to physiology and / or metabolism. This review describes various approaches that have been taken toward the development of responsive contrast agents and discusses the importance of fast water exchange for advancement of targeted Gd3+-based agents with higher sensitivity. The recent discovery of Eu3+ complexes having extraordinarily slow water exchange has opened a new avenue in contrast agent design based upon the chemical exchange saturation transfer (CEST) mechanism. These new paramagnetic complexes called PARACEST agents offer new possibilities …
Synthesis, Relaxometric And Photophysical Properties Of A New Ph-Responsive Mri Contrast Agent: The Effect Of Other Ligating Groups On Dissociation Of A P-Nitrophenolic Pendant Arm, Mark Woods, Garry Kiefer, Simon G. Bott, Aminta Castillo-Muzquiz, Carrie Eshelbrenner, Lydie Michaudet, Kenneth Mcmillan, Siva D.K. Mudigunda, Doug Ogrin, Gyula Tircso, Shanrong Zhang, Piyu Zhao, A. Dean Sherry
Synthesis, Relaxometric And Photophysical Properties Of A New Ph-Responsive Mri Contrast Agent: The Effect Of Other Ligating Groups On Dissociation Of A P-Nitrophenolic Pendant Arm, Mark Woods, Garry Kiefer, Simon G. Bott, Aminta Castillo-Muzquiz, Carrie Eshelbrenner, Lydie Michaudet, Kenneth Mcmillan, Siva D.K. Mudigunda, Doug Ogrin, Gyula Tircso, Shanrong Zhang, Piyu Zhao, A. Dean Sherry
Chemistry Faculty Publications and Presentations
Two gadolinium(III) chelates, GdNP-DO3A (1-methlyene-(p-NitroPhenol)-1,4,7,10-tetraazacycloDOdecane-4,7,10-triAcetate) and GdNP-DO3AM (1-methlyene(p-NitroPhenol)-1,4,7,10-tetraazacycloDOdecane-4,7,10-triacetAMide), containing a single nitrophenolic pendant arm plus either three acetate or three amide pendant arms were synthesized and characterized. The properties of the gadolinium, terbium, and dysprosium complexes of these ligands were examined as a function of pH. The extent and mechanism of the changes in water relaxivity with pH of each gadolinium complex was found to differ substantially for the two complexes. The water relaxivity of Gd(NP-DO3A) increases from 4.1 …