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Full-Text Articles in Physical Sciences and Mathematics
Synthesis, Characterization, And Kinetics Studies Of New Cobalt Complexes For The Production Of H2 In Acidic Media, Michael John Celestine
Synthesis, Characterization, And Kinetics Studies Of New Cobalt Complexes For The Production Of H2 In Acidic Media, Michael John Celestine
Chemistry & Biochemistry Theses & Dissertations
The kinetics and mechanism of the oxidation of [Co(dmgBF2)2(OH2)2] (where dmgBF2 = difluoroboryldimethylglyoximato) by sodium hypochlorite (NaOCl), sodium bromate (NaBrO3), and bromine (Br2) was investigated by stopped-flow spectrophotometry at 450 nm over a wide temperature range. The pKa1 value for [Co(dmgBF2)2(OH2)2] was calculated as 5.27 ± 0.14 at I = 0.60 (NaCl). From the variation in pH studies, the activation parameters were derived from the proposed mechanisms for NaOCl, ΔH1*, ΔH2*, ΔS1*, and …
Synthesis And Mechanistic Investigations Of Transition Metal Complexes And Ligands For Chemotherapeutic Applications, Jimmie Lee Bullock Jr.
Synthesis And Mechanistic Investigations Of Transition Metal Complexes And Ligands For Chemotherapeutic Applications, Jimmie Lee Bullock Jr.
Chemistry & Biochemistry Theses & Dissertations
Transition metal complexes have played a critical role in antitumor therapy with many complexes incorporating platinum, ruthenium, and lanthanum having been investigated in preclinical and clinical trials. The best known transition metal therapeutic is cisplatin, which is utilized in nearly 50% of all cancer therapies, despite its significant toxic side effects. The toxic side effects of current FDA approved platinum-based chemotherapeutics are often overlooked due to the “special status” granted to these drugs due to their ability to fight, what is often considered an incurable disease with life expectancies often measured in months. Oncology drug development has therefore now focused …