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Ligand-Based Drug Design : I. Conformational Studies Of Gbr 12909 Analogs As Cocaine Antagonists; Ii. 3d-Qsar Studies Of Salvinorin A Analogs As Kappa Opioid Agonists, Deepangi Pandit

Dissertations

Ligand-based drug design (LBDD) techniques are applied when the structure of the receptor is unknown but when a series of compounds or ligands have been identified that show the biological activity of the interest. Generally, availability of a series of compounds with high activity, with no activity, and also with a range of intermediate activities for the desired biological target is required. It is common that structures of membrane-bound proteins (for example, monoamine transporter proteins and opioid receptor proteins) are unknown as these proteins are notoriously difficult to crystallize.

In Part I of this study, analogs of the flexible dopamine …