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Full-Text Articles in Physical Sciences and Mathematics
One-Pot Preparation Of 1,3-Dihydro-1- (Trifluoromethyl)Isobenzofuran-1-Ol Derivatives From 1,2-Dibromobenzene, Daniel Becker, Hui Li, Daniel L. Flynn
One-Pot Preparation Of 1,3-Dihydro-1- (Trifluoromethyl)Isobenzofuran-1-Ol Derivatives From 1,2-Dibromobenzene, Daniel Becker, Hui Li, Daniel L. Flynn
Chemistry: Faculty Publications and Other Works
A one-pot method for the preparation of 1,3-dihydro-1-(trifluoromethyl)isobenzofuran-1-ol derivatives 5from 1,2-dibromobenzene is described
Preparation Of Trifluoromethyl Lactol Derivatives Via Base Initiated Cyclobutanol Ring Opening To A Laterally Lithiated Trifluoromethyl Ketone, Daniel Becker, Daniel L. Flynn
Preparation Of Trifluoromethyl Lactol Derivatives Via Base Initiated Cyclobutanol Ring Opening To A Laterally Lithiated Trifluoromethyl Ketone, Daniel Becker, Daniel L. Flynn
Chemistry: Faculty Publications and Other Works
Benzocyclobutenone derivatives 4 are converted to the corresponding trifluoromethylcyclobutanols 5 by treatment with trifluoromethyltrimethylsilane in the presence of tetra-n-butylammonium fluoride. These trifluoromethylcyclobutanol derivatives are then treated with LiTMP in the presence of aromatic aldehydes to afford trifluoromethyllactols 6 via a laterally-lithiated trifluoromethylketone intermediate.