Physical Sciences and Mathematics Commons^™

Adaptation Of Pt-Dna Binding Experiments Into A Multiweek Upperlevel Biochemistry Laboratory Activity, Keira Naff

Fall Showcase for Research and Creative Inquiry

Platinum-based drugs are commonly used as anti-cancer therapeutics due to their abilities to bind to DNA and prohibit proliferation in cells. Although the concept of drug interactions within biomolecules is often introduced in undergraduate courses such as biochemistry and toxicology, there are very few laboratory activities that exist that provide undergraduate students with the opportunity to investigate this topic in the lab. During the Summer 2020 PRISM program, we worked to create a multi-week laboratory activity for upper-level biochemistry students focused on the investigation of the DNA binding abilities of common Pt anticancer therapeutics through biochemical modeling and wet laboratory …

Chem 403: Analysis Of Arsenic In Wine Using Xrf, Hannah Meyls

2020 Virtual Spring Student Showcase for Research and Creative Inquiry

Arsenic contamination in food and beverages is a problem due to the harm it can cause consumers. Currently in the United States there is no regulation limit. Red, white, and pink wines will be analyzed for their concentration of inorganic arsenic. Analysis of the wines will be analyzed by x-ray fluorescence spectroscopy (XRF). From this experiment we hope to develop a new method for measuring low concentrations of arsenic in wine.

Volume 12, Haleigh James, Hannah Meyls, Hope Irvin, Megan E. Hlavaty, Samara L. Gall, Austin J. Funk, Karyn Keane, Sarah Ghali, Antonio Harvey, Andrew Jones, Rachel Hazelwood, Madison Schmitz, Marija Venta, Haley Tebo, Jeremiah Gilmer, Bridget Dunn, Benjamin Sullivan, Mckenzie Johnson

Incite: The Journal of Undergraduate Scholarship

Introduction, Dr. Roger A. Byrne, Dean

From the Editor, Dr. Larissa "Kat" Tracy

From the Designers, Rachel English, Rachel Hanson

Immortality in the Mortal World: Otherworldly Intervention in "Lanval" and "The Wife of Bath's Tale" by Haleigh James

Analysis of Phenolic Compounds in Moroccan Olive Oils by HPLC by Hannah Meyls

Art by Hope Irvin

The Effects of Cell Phone Use on Gameplay Enjoyment and Frustration by Megan E. Hlavaty, Samara L. Gall, and Austin J. Funk

Care, No Matter What: Planned Parenthood's Use of Organizational Rhetoric to Expand its Reputation by Karyn Keane

Analysis of Petroleum Products for …

Analysis Of Petroleum Products For Forensic And Environmental Applications, Sarah Ghali, Sarah Porter

2020 Virtual Spring Student Showcase for Research and Creative Inquiry

In both forensic and environmental applications, it is often important to identify ignitable liquid (IL) residues, to find a suspect or to clean up an oil spill. The ASTM method is commonly used; the extraction methods vary, but the data collection is the same. The instrument used in the ASTM method is gas chromatography mass spectroscopy (GC-MS), which allows a visual identification of the IL contaminating the sample. In this study, the use of Fourier transform infrared spectrometry (FTIR) was used in conjunction with chemometric analysis. Samples were prepared were to simulate an oil spill in natural waters. Two chemometric …

Analysis Of Phenolic Compounds In Moroccan Olive Oils By Hplc, Hannah Meyls, Sarah Porter

2020 Virtual Spring Student Showcase for Research and Creative Inquiry

Five extra virgin olive oils collected from farms in Morocco were analyzed for phenolic compounds. To complement these data, the chemical composition of the olive oils were analyzed by high-performance liquid chromatography. Several phenolic compounds were identified and quantified in the olive oils. Specifically, levels of oleuropein and luteolin were quantified in the low mg/kg range, and qualitative comparisons were made between the oil samples for tyrosol, vanillic acid, and apigenin. To compare extraction efficiency of different extraction solvents, methanol and DMF were used.

Synthesis Of Substituted Stilbene Probes Towards The Investigation Of Antagonistic Effects Observed With 3,5-Substituted Paraben Derivatives, Bethany Adams

Longwood Senior Theses

In practice, antagonistic xenoestrogen compounds have been used as drugs to treat cancer. Traditional strategies, include preparation of estrogen receptor antagonists exhibiting high affinity for the receptor while preventing rearrangement of the AF-2 binding domain. In a potentially new strategy, substituted parabens have proven to act as antagonists but do not bear the large sidechain associated with this common antagonist strategy. Weak phenolic interactions make determining such paraben binding confirmations and mode of action difficult. To investigate these activities associated with hindered phenolic compounds, substituted bisphenol probes have been synthesized via Wittig protocols to produce a series of stilbene derivatives. …