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Full-Text Articles in Physical Sciences and Mathematics
Rational Drug Design For Neglected Diseases: Implementation Of Computational Methods To Construct Predictive Devices And Examine Mechanisms, Catharine Jane Collar
Rational Drug Design For Neglected Diseases: Implementation Of Computational Methods To Construct Predictive Devices And Examine Mechanisms, Catharine Jane Collar
Chemistry Dissertations
Over a billion individuals worldwide suffer from neglected diseases. This equates to approximately one-sixth of the human population. These infections are often endemic in remote tropical regions of impoverished populations where vectors can flourish and infected individuals cannot be effectively treated due to a lack of hospitals, medical equipment, drugs, and trained personnel. The few drugs that have been approved for the treatments of such illnesses are not widely used because they are riddled with inadequate implications of cost, safety, drug availability, administration, and resistance. Hence, there exists an eminent need for the design and development of improved new therapeutics. …
Diagnosis And Inhibition Tools In Medicinal Chemistry, Senol Akay
Diagnosis And Inhibition Tools In Medicinal Chemistry, Senol Akay
Chemistry Dissertations
Cell surface saccharides are involved in a variety of essential biological events. Fluorescent sensors for saccharides can be used for detection, diagnosis, analysis and monitoring of pathological processes. The boronic acid functional group is known to bind strongly and reversibly to compounds with diol groups, which are commonly found on saccharides. Sensors that have been developed for the purpose of saccharide recognition have shown great potential. However, they are very hydrophobic and this lack of essential water-solubility makes them useful in biological applications. The first section of this dissertation details the process of developing water-soluble saccharide sensors that change fluorescent …