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Full-Text Articles in Physical Sciences and Mathematics
Aspires At Georgia Southern University, Christine R. Whitlock, Bret S. Danilowicz, Gus J. Molina, Lisa S. Vance
Aspires At Georgia Southern University, Christine R. Whitlock, Bret S. Danilowicz, Gus J. Molina, Lisa S. Vance
Department of Chemistry and Biochemistry Faculty Presentations
Advisement and Scholarship Promoting Inquiry-based Research Experiences in STEM (ASPIRES) at Georgia Southern University is a comprehensive, strategic project that will increase the number of students graduating with bachelor's degrees in STEM fields. Five action items address two interrelated goals: (1) to increase retention of STEM students and (2) to improve academic success in science and math courses. The project ended in 2012.
Disassembly Of Preformed Amyloid Ss Fibrils By Small Organofluorine Molecules, Abha Sood, Abid Shaikh, Catharine Sauer, Samson Hailemichael, Michelle Foster, Béla Török, Marianna Török
Disassembly Of Preformed Amyloid Ss Fibrils By Small Organofluorine Molecules, Abha Sood, Abid Shaikh, Catharine Sauer, Samson Hailemichael, Michelle Foster, Béla Török, Marianna Török
Abid Shaikh
A potential therapeutic approach for Alzheimer’s disease is to reduce the amount of toxic amyloid-beta oligomers and fibrillar amyloid plaques. In order to contribute to this approach the ability of small organofluorine compounds that were previously reported as successful inhibitors of fibrillogenesis to destabilize preformed fibrils of the amyloid-beta peptide was studied. These organofluorine molecules including chiral compounds were tested in vitro using standard methods based on Thioflavin-T (THT) fluorescence spectroscopy, atomic force microscopy (AFM) and Fourier-transform infrared spectroscopy (FTIR). It was observed that 5′-halogen substituted 3,3,3-trifluoromethyl-2-hydroxyl-(indol-3-yl)-propionic acid esters showed significant activity in the disassembly of the preformed fibrils. Since …
Boronic Acid Functionalized Peptidyl Synthetic Lectins: Combinatorial Library Design, Peptide Sequencing, And Selective Glycoprotein Recognition, Kevin L. Bicker, Jing Sun, John J. Lavigne, Paul R. Thompson
Boronic Acid Functionalized Peptidyl Synthetic Lectins: Combinatorial Library Design, Peptide Sequencing, And Selective Glycoprotein Recognition, Kevin L. Bicker, Jing Sun, John J. Lavigne, Paul R. Thompson
Jing Sun
Aberrant glycosylation of cell membrane and secreted glycoproteins is a hallmark of various disease states, including cancer. The natural lectins currently used in the recognition of these glycoproteins are costly, difficult to produce, and unstable toward rigorous use. Herein we describe the design and synthesis of several boronic acid functionalized peptide-based synthetic lectin (SL) libraries, as well as the optimized methodology for obtaining peptide sequences of these SLs. SL libraries were subsequently used to identify SLs with as high as 5-fold selectivity for various glycoproteins. SLs will inevitably find a role in cancer diagnostics, given that they do not suffer …