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Full-Text Articles in Physical Sciences and Mathematics
Interaction Between Fragments Of Tau Protein Investigated By Force Spectroscopy Using Afm, Anad Mohamed Afhaima
Interaction Between Fragments Of Tau Protein Investigated By Force Spectroscopy Using Afm, Anad Mohamed Afhaima
Theses and Dissertations
Over the last couple of decades, there has been rapidly growing interest in research of natively unfolded proteins. Some proteins from this group are implicated in a number of neurodegenerative diseases. One group of neurodegenerative diseases, taupathies, is associated with tau protein. A number of biophysical and spectroscopic studies have revealed that tau protein can expand to a largely extended state and to transition rapidly between many different conformations. Although many of the techniques that elucidate structure of macromolecules have provided important information about the folded states of proteins, important information about the transition between the extended conformation states remain …
Metastable-State Photoacids And The Related Photo-Responsive Polymers, Zhuozhi Wang
Metastable-State Photoacids And The Related Photo-Responsive Polymers, Zhuozhi Wang
Theses and Dissertations
Metastable-state photoacid is a type of photo-sensitive compounds that can release large amount of protons reversibly upon visible-light irradiation. Since being developed by our group in 2011, metastable-state photoacid has been utilized to develop many applications that involve controlling proton transfer processes. Since proton transfer process is one of the most common processes in nature, metastable-state photoacid is a powerful tool to control various processes with light. A introduction of metastable state photoacid is described in Chapter 1. In Chapter 2, metastable-state photoacids with different substituents were designed to study the relationship between their structures and physicochemical properties. In Chapter …
Surface Modification Of Core-Shell Silver-Titania Nanocomposites With Copper Bipyridine–Phosphonates And Studies On Ag@Tio₂ Mediated Degradation Of Organophosphates, Somayeh Talebzadeh Farooji
Surface Modification Of Core-Shell Silver-Titania Nanocomposites With Copper Bipyridine–Phosphonates And Studies On Ag@Tio₂ Mediated Degradation Of Organophosphates, Somayeh Talebzadeh Farooji
Theses and Dissertations
Silver nanoparticles, coated with a titania shell were prepared and were shown to be catalytically active for the rapid degradation of organothiophosphate methyl parathion (MeP). Formation of the degradation product, p-nitrophenolate (PNP) was monitored as a function of pH, using UV-Vis spectroscopy, and 31P NMR spectroscopy confirmed the hydrolysis is the predominant pathway for substrate breakdown under non-photocatalytic degradation. We have demonstrated that the unique combination of TiO2 and silver nanoparticles is required for catalytic hydrolysis with good reproducibility. This work represents the first example of MeP degradation using TiO2 doped with AgNP under mild and ambient conditions. It is …
5-Oxo-Ete Antagonists In Allergic Disease; Design And Synthesis Of Affinity Chromatography Ligand For 5-Hedh; And Synthesis Of Isoprostanes As An Index For The Diagnosis In Alzheimer’S Disease, Qiuji Ye
Theses and Dissertations
Arachidonic acid (AA, 4, Figure 1) is a 20:4 (ω-6) fatty acid with a 20-carbon chain and four cis-double bonds, and the esterified form of AA in phospholipids can be enzymatically liberated by phospholipases (PL) and subsequently metabolized into a variety of physiologically important mediators known as eicosanoids (Figure 2). One of the most important eicosanoids is 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE, 17). The 5-oxo-ETE (17) is the most known potent chemotactic factors for human eosinophils, and it can stimulate the late-phase asthma attacks.¹ To determine how the biosynthesis of 5-oxo-ETE is regulated, so as to determine its pathophysiological roles in the …
Metastable-State Nh Photoacids And Organic Photo Carbon Monoxide Releasing Materials, Aluthwatte Rallage Nawodi Madhusanka Abeyrathna
Metastable-State Nh Photoacids And Organic Photo Carbon Monoxide Releasing Materials, Aluthwatte Rallage Nawodi Madhusanka Abeyrathna
Theses and Dissertations
The recently discovered metastable-state photoacids (mPAHs) can produce a large proton concentration with high efficiency and good reversibility upon irradiation with visible light with moderate intensity. Therefore, mPAHs can be conveniently incorporated in to different systems to control various proton-transfer processes. Recently, several applications of mPAHs have been demonstrated. However, none of the previously reported mPAHs can function at a pH 7.4. Thus, biological applications of mPAHs are limited. In this work, mPAHs that can reversibly release a proton in PBS buffer (pH = 7.4) under visible light are designed and synthesized. NH-PAH-1 is the first of this type of …
Part (I): Synthesis, Characterization And Antibacterial Activity Of Vanadium(V) Complexes With Ons Schiff Bases Part (Ii): Synthesis Of 9-Cd₃-11-Cis-Retinal For The Investigation Of The Activation Mechanism Of Gpcr Rhodopsin By Solid-State ²H Nmr Spectroscopy, Samira M. Faylough
Theses and Dissertations
Vanadium compounds are known to play many roles in both biology and industry, and the biochemical activity of these compounds has led to their increased importance in both biological and medical research. In the present work, some new substituents for hydrazinecarbodithioate Schiff base ligands and their dioxo vanadium(V) complexes were synthesized and characterized by ¹H NMR, ¹³C NMR, DART mass, FT-IR, UV-vis, fluorescence spectrometer, and single X-ray diffraction analysis for complex K[VO₂{(S-benzyl-3-(2-hydroxy-5-nitrophenyl) methylene dithiocarbazate)}] (212). Dioxovanadium(V) complexes K[VO₂{(S-methyl-3-(2-hydroxy-5-nitrophenyl)methylenedithiocarbazate)}] (211) and 212 have been tested for antibacterial activity against Burkholderia pseudomallei and Burkholderia mallei strains. Ceftazidime was used as a reference …