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Physical Sciences and Mathematics Commons

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Chemistry

East Tennessee State University

Electronic Theses and Dissertations

Theses/Dissertations

2011

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Full-Text Articles in Physical Sciences and Mathematics

Using Electrochemical Method To Study The Interaction Between Dna And A Compound Known To Have Anticancer Property., Alexander Kamasah Dec 2011

Using Electrochemical Method To Study The Interaction Between Dna And A Compound Known To Have Anticancer Property., Alexander Kamasah

Electronic Theses and Dissertations

The interaction of 4-(1'-[8'-(1''-pyrenyl)naphthyl])-2,6-diaminopyridine bis-glycamide bishydrocholride known to have anticancer properties with deoxyribonucleic acid (DNA) had been studied on a modified gold electrode by self-assembled monolayer using cyclic voltammetry. K4Fe (CN)6 was used as a probe to obtain electrochemical information on the electrode surface.

A bare gold (Au) electrode was modified with cysteamine and our results showed no change in the limiting steady state current as compared to the bare Au electrode. There was a reduction in the steady state current after the modification of the gold electrode with DNA. Immobilization of the DNA modified gold electrode …