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Structural Studies Of Bile Salt Aggregation By Nuclear Magnetic Resonance Spectroscopy And Mass Spectrometry, Nicholas Doyle
Structural Studies Of Bile Salt Aggregation By Nuclear Magnetic Resonance Spectroscopy And Mass Spectrometry, Nicholas Doyle
Master’s Theses
Bile salts are biomolecules that are produced in the liver and are responsible for a range of functions in the process of digestion, primarily the emulsification of dietary fat and fat-soluble vitamins. Despite their importance in biological chemistry, the structure and dynamics of bile salt aggregation are not well understood. The efforts described herein attempt to enhance the understanding of cholate aggregation numbers (AN), critical micelle concentration (CMC), micellar structure(s), and interactions with a binaphthyl probe molecule. Cholate is the most common bile salt in mammals and is, therefore, a decent model for describing bile salt aggregation. CMC determination is …