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Full-Text Articles in Physical Sciences and Mathematics
Searching For Nascent Peptides That Cause Ribosome Stalling, Shankar Parajuli, Dr. Allen Buskirk
Searching For Nascent Peptides That Cause Ribosome Stalling, Shankar Parajuli, Dr. Allen Buskirk
Journal of Undergraduate Research
Ribosomes are molecular machines that synthesize all the proteins for all living cells. Ribosomes sometimes stall and cannot complete the synthesis of a given protein. Some peptides interact with the ribosome during their own translation and induce stalling.1 The SecM and TnaC peptides in E. coli, for example, have been found to play a key regulatory role in translation of genes found on the same mRNA.2
Synthesis And Purification Of The Glycosphingolipid Csa-13, Tyler Olsen, Dr. Paul Savage
Synthesis And Purification Of The Glycosphingolipid Csa-13, Tyler Olsen, Dr. Paul Savage
Journal of Undergraduate Research
The need for novel antibiotic mechanisms is prevalent. Common antimicrobial medicines such as penicillin, ampicillin and vancomycin have started becoming obsolete as resistant strains of bacteria become more widespread. The main problem with antibiotics is the rapid mutations that bacteria undergo. Eventually one cell will develop resistance, and then have that mutation selected for as patients undergo antibiotic therapy. Bacteria are rapidly changing to combat the many new antibiotic variants that have come out.
Synthesis Of S-Equol Using Heck Coupling Reaction And Phase-Transfer Catalysis, Chelsey Hancock
Synthesis Of S-Equol Using Heck Coupling Reaction And Phase-Transfer Catalysis, Chelsey Hancock
Journal of Undergraduate Research
Please list all accomplishments, achievements, publications, presentations, or other scholarly productivity that resulted from your ORCA project. This may include submissions to peer-reviewed journals, conference presentations or papers, performances, exhibitions, internships, scholarships, graduate school opportunities, local presentations, or awards that followed your mentoring experience.
The Total Synthesis Of S-Equol Using Phase Transfer Catalysis, Eric Bready, Dr. Merritt Andrus
The Total Synthesis Of S-Equol Using Phase Transfer Catalysis, Eric Bready, Dr. Merritt Andrus
Journal of Undergraduate Research
The purpose of this project was completion of the total organic synthesis of the anti-cancer compound (S)-equol. My goal was to carry out our planned synthesis of this molecule using Phase Transfer Catalysts, (PTCs), which promote the formation of the S enantiomer as opposed to the R enantiomer of equol (S and R enantiomers are like right and left hands, which are mirror images of each other—in organic synthesis usually only one form is desired) (1). In using PTCs it was our hope that we would be able to form (S)-equol with high yield and in a timely manner. Successful …
Facile Synthesis And Characterization Of A Thermally Stable Silica-Doped Alumina With Tunable Surface Area, Porosity, And Acidity, Maryam Khosravi Mardkhe
Facile Synthesis And Characterization Of A Thermally Stable Silica-Doped Alumina With Tunable Surface Area, Porosity, And Acidity, Maryam Khosravi Mardkhe
Theses and Dissertations
Mesoporous γ-Al2O3 is one of the most widely used catalyst supports for commercial catalytic applications. The performance of a catalyst strongly depends on the combination of textural, chemical and physical properties of the support. Pore size is essential since each catalytic system requires a unique pore size for optimal catalyst loading, diffusion and selectivity. In addition, high surface area and large pore volume usually result in higher catalyst loading, which increases the number of catalytic reaction sites and decreases reaction time. Therefore, determination of surface area and porosity of porous supports is critical for the successful design and optimization of …
Synthesis Of Bioconjugate Dimers Used To Probe The Structure Of Pglycoprotein, Emily Parker, Dr. Merritt B. Andrus
Synthesis Of Bioconjugate Dimers Used To Probe The Structure Of Pglycoprotein, Emily Parker, Dr. Merritt B. Andrus
Journal of Undergraduate Research
Chemotherapy is one of the primary treatments for cancer today. A patient’s life may depend on its efficacy, so when he or she develops multi-drug resistance (MDR) the results can be devastating. MDR, a clinical condition manifested by the failure of chemotherapy, is primarily due to the expression of P-glycoprotein (Pgp), a membrane-bound small molecule transport protein which is found normally in some cells but is greatly over expressed in drug resistant cancer cells1. It is believed that after chemotherapy drugs diffuse into the cell, Pgp effluxes them out using energy from ATP hydrolysis, thus imparting drug resistance.