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Full-Text Articles in Physical Sciences and Mathematics
High Pressure Liquid Chromatographic Methods For The Separations Of Derivatized Alpha-Keto Acids And Thiamine Phosphate Esters, Bruce Clark Hemming
High Pressure Liquid Chromatographic Methods For The Separations Of Derivatized Alpha-Keto Acids And Thiamine Phosphate Esters, Bruce Clark Hemming
Theses and Dissertations
Improved methods have been developed for separation of a-keto acid derivatives and for thiamine and its phosphate esters. Linear gradient reverse phase chromatography using ion-pair formation provides baseline resolution for a seven-component homologous series of a-keto acid dinitrophenylhydrazones having increasing carbon chain lengths. Branched-chain keto acids can also be separated. Aldehyde derivatives were examined as possible interfering compounds. Peak identification in biological material was confirmed for pyruvate by an enzymic peak shift technique. Monitoring near 365 nm permits low nanogram detection. Preliminary studies of keto acids in biological material illustrate the method's applicability. The same system with slight changes separates …
The Synthesis Of Novel Macrocyclic Multidentate Compounds From Dioxodioic Acids (1), R. Elliott Asay
The Synthesis Of Novel Macrocyclic Multidentate Compounds From Dioxodioic Acids (1), R. Elliott Asay
Theses and Dissertations
A series of novel macrocyclic multidentate crown compounds have been prepared from a series of dioxodioic acids. The dioxodioic acids were prepared by treating various oligoethylene glycols or amines with maleic, succinic, citraconic, and glutaric anhydrides. The crown compounds were then synthesized from the dioxodioic acid chlorides obtained from the diacids and various oligoethylene glycols or ethylene diamine.