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Articles 1 - 8 of 8
Full-Text Articles in Physical Sciences and Mathematics
Investigation Of The Cellular Uptake And Cytotoxicity Of Ruthenium(Ii) Polypyridyl Complexes As A Function Of Lipophilicity, Matthew Guerrero
Investigation Of The Cellular Uptake And Cytotoxicity Of Ruthenium(Ii) Polypyridyl Complexes As A Function Of Lipophilicity, Matthew Guerrero
Chemistry & Biochemistry Theses
Ru(II) polypyridyl complexes have been one of the focal points of investigation for inorganic anti-cancer drugs, as they are robust enough to remain chemically intact in vivo and many show potent cytotoxicty. In particular, the RPC [Ru(dip)3]2+, where dip is 4,7-diphenyl-1,10-phenanthroline, is noted for its high cytotoxicity (IC50 ~2-5 uM) across a broad spectrum of cancer cell lines and more recently has been implicated as targeting microtubules, which is an unusual target for metal-based drugs. While the cellular uptake for [Ru(dip)3]Cl2 is among the highest seen for RPCs, its solubility in water or buffer is limited and problematic. In order …
Total Synthesis Of Mansouramycin A, Abigail M. Zepeda
Total Synthesis Of Mansouramycin A, Abigail M. Zepeda
Theses and Dissertations
In 2009 bioactive compounds from marine Streptomyces species was isolated which resulted in deriving four isoquinoline-quinone alkaloids known as Mansouramycins A-D. There have been reports that there are 36 non-small cancer cells against cytotoxicity in Mansouramycins A-C in lung cancer, breast cancer, melanoma, and prostate cancer cells. Reports that have conducted total syntheses were all specific to a single compound only Mansouramycin A and D. However, in precedent methods, to obtain the derivatives with different substituents are limited when the substituents are on the fused-pyridine ring. Thus, a develop a systematic synthetic methods of isoquinoline-quinones, which are to be able …
Synthesis And Characterization Of Antimony Cyanoximates For Microbiological Studies, Seth Adu Amankrah
Synthesis And Characterization Of Antimony Cyanoximates For Microbiological Studies, Seth Adu Amankrah
MSU Graduate Theses
Antibiotic-resistant pathogenic microorganisms (such as MRSA and alike) represent a real and significant threat to the health and wellbeing of the general population. The search for new compounds of non-antibiotic nature that act as antimicrobial agents is an important task with obvious practical applications in the biomedical field. Metal-based coordination and organometallic compounds that demonstrate antimicrobial activity was found to exhibit a completely different mode of action compared to antibiotics. That suggests the absence of the mechanism of developing tolerance to these types of compounds at least for 30 - 40 years. Thus, there are numerous organotin (IV), silver (I), …
Major Chemical Constituents From Illicium Griffithii Hook. F. & Thoms Of North East India And Their Cytotoxicity And Antimicrobial Activities, Deepjyoti Dutta, Bardwi Narzary, Snigdha Saikia, Kashyap J. Tamuli, Manobjyoti Bordoloi, Neipihoi Lhouvum, Shyamalendu Nath, Ranjan K. Sahoo, Barnali Gogoi, Surovi Saikia, Nayan K. Bhattacharyya
Major Chemical Constituents From Illicium Griffithii Hook. F. & Thoms Of North East India And Their Cytotoxicity And Antimicrobial Activities, Deepjyoti Dutta, Bardwi Narzary, Snigdha Saikia, Kashyap J. Tamuli, Manobjyoti Bordoloi, Neipihoi Lhouvum, Shyamalendu Nath, Ranjan K. Sahoo, Barnali Gogoi, Surovi Saikia, Nayan K. Bhattacharyya
Turkish Journal of Chemistry
Illicium griffithii Hook. f. & Thoms is an endemic medicinal plant of North East India found in the Eastern Himalayan region of biodiversity mega centre. Herein, chemical investigation of I. griffithii, afforded five compounds and their structures were determined through extensive use of NMR, HRMS, and FT-IR spectroscopy. The complete proton-proton, proton-carbon coupling network of compound 1 was determined using 1H-1H COSY, HSQC and NOESY NMR experiments. All the compounds were evaluated for their cytotoxic activity by MTT assay and antimicrobial activity by Agar well diffusion method. Compound 1 exhibited significant cytotoxicity activity against Lung cancer (A549) and pancreatic …
Release Of Nifedipine, Furosemide, And Niclosamide Drugs From The Biocompatible Poly(Hema) Hydrogel Structures, Bahar Yilmaz
Release Of Nifedipine, Furosemide, And Niclosamide Drugs From The Biocompatible Poly(Hema) Hydrogel Structures, Bahar Yilmaz
Turkish Journal of Chemistry
The primary aim of this article was to improve the solubility and bioavailability of the drugs nifedipine, niclosamide, and furosemide due to their poor solubility and dissolution rate. Therefore, these drugs require improvement in solubility and dissolution rate in formulation development, especially in solid dosage forms such as hydrogels and capsules. Hydrogel structures were synthesized by using a biocompatible, nontoxic, and protective pure 2-hydroxy ethyl methacrylate (HEMA) monomer. These hydrogel structures were characterized by various techniques such as scanning electron microscopy and Fourier-transformed infrared spectroscopy. In the next step, drug molecules were loaded in the poly (HEMA) hydrogels. Drug releases …
Thio-Schiff Bases Derived From 2,2'-Disulfanedianiline Via Nanocerium Oxide: Antimicrobial Effect And Antiproliferative Effects In Melanoma Cells, Aslihan Dalmaz, Sefa Durmuş, Görkem Dülger, Merve Alpay
Thio-Schiff Bases Derived From 2,2'-Disulfanedianiline Via Nanocerium Oxide: Antimicrobial Effect And Antiproliferative Effects In Melanoma Cells, Aslihan Dalmaz, Sefa Durmuş, Görkem Dülger, Merve Alpay
Turkish Journal of Chemistry
In this study, the synthesis of dimeric disulfide-Schiff bases was carried out using two methods. The structures of the obtained Schiff bases were elucidated by various spectroscopic methods as well as elemental analysis. The Schiff base derivative compounds (3a-6) were screened for in vitro antibacterial activity against multidrug-resistant microorganisms using microdilution method. All the tested compounds showed varying inhibition zones against the pathogens. According to MIC results, the compound 2 was shown strong inhibitory activity against all the tested microorganisms compared to antibiotics. In addition, all the tested compounds showed different antiproliferative effects on the melanoma cell line (B16F10). Our …
Comprehensive Evaluation Of Reseda Lutea L. (Wild Mignonette) And 7 Isolated Flavonol Glycosides: Determination Of Antioxidant Activity, Anti-Alzheimer, Antidiabetic And Cytotoxic Effects With In Vitro And In Silico Methods, Hati̇ce Kiziltaş
Turkish Journal of Chemistry
In this study, anticholinergic, antidiabetic, antioxidant and cytotoxic activities of Reseda lutea L. (R. lutea) were determined. Ethanol extracts of R. lutea (EERL) and water extract of R. lutea (WERL) were prepared for biochemical analysis. The antioxidant capacities of EERL and WERL were evaluated with 6 different methods. In addition, acetylcholinesterase (AChE), α-amylase and α-glycosidase enzyme inhibition by EERL were measured. According to the results, EERL exhibited high inhibition effects against α-amylase, α-glycosidase and AChE enzymes. The IC50 values of EERL against AChE (2.21 μg/mL), α-glycosidase (1.38 μg/mL), and α-amylase (0.11 μg/mL) were determined. Also, high cytotoxic effect of EERL …
Investigation Of Boron Nanosized Particles Prepared With Various Surfactants And Chitosan In Terms Of Physical Stability And Cell Viability, Emrah Özakar, Mehmet Semi̇h Bi̇ngöl, Ruki̇ye Sevi̇nç Özakar
Investigation Of Boron Nanosized Particles Prepared With Various Surfactants And Chitosan In Terms Of Physical Stability And Cell Viability, Emrah Özakar, Mehmet Semi̇h Bi̇ngöl, Ruki̇ye Sevi̇nç Özakar
Turkish Journal of Chemistry
Nanosuspensions (NS) are one of the new generation drug carrier forms developed to overcome the deficiencies of drugs with poor water solubility or insolubility and are considered to be one of the most successful approaches to formulate compounds in recent years. Boron nitride (BN) is insoluble in water and chemically more stable than carbon, it offers better biological superiority although the application of carbon structures in the biomedical field has increased in recent years. Chitosan is a polymer with excellent processability and biocompatibility thanks to its high dielectric constant. In addition, chitosan has a high affinity for metal ions. This …