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Full-Text Articles in Physical Sciences and Mathematics
Determining The Site Specific Metal Binding And Structural Properties Of Ef-Hand Protein Using Grafting Approach, Hsiau-Wei Lee
Determining The Site Specific Metal Binding And Structural Properties Of Ef-Hand Protein Using Grafting Approach, Hsiau-Wei Lee
Chemistry Dissertations
Calmodulin is an essential EF-hand protein with a helix-loop-helix calcium binding motif. Understanding Ca(II) dependent activation of calmodulin and other EF-hand proteins is limited by Ca(II)-induced conformational change, multiple and cooperative binding of Ca(II) ions, and interactions between the paired EF-hand motifs. The goal of this research project is to probe key determinants for calcium binding properties and pairing interactions at the site specific level using a grafting approach and high resolution NMR. An individual Ca(II) binding site of the EF-hand motifs of calmodulin was grafted into a non-calcium dependent protein, CD2, to bypass limitations associated with natural EF-hand proteins …
Structure And Energetics Of Rna - Protein Interactions For Hiv Rreiib Targeting Zinc Finger Proteins., Subrata H. Mishra
Structure And Energetics Of Rna - Protein Interactions For Hiv Rreiib Targeting Zinc Finger Proteins., Subrata H. Mishra
Chemistry Dissertations
RNA - protein interactions constitute a vital part of numerous biochemical processes. In the HIV life cycle, the interaction of the viral protein Rev and the Rev Responsive Element (RRE), a part of unspliced HIV RNA, is crucial for the propagation of infectious virions. Intervention of this interaction disrupts the viral life cycle. Rev - RRE interaction initially occurs at a high affinity binding site localized to a relatively small stem loop structure called RREIIB. This binding event has been well characterized by a variety of biochemical, enzymatic and structural studies. Our collaborators have previously demonstrated the efficacy of zinc …
Exploration Of Gradient-Type Poly(Arylene Ether)S Via An Abb' Monomer System, Alex V. Dolgov
Exploration Of Gradient-Type Poly(Arylene Ether)S Via An Abb' Monomer System, Alex V. Dolgov
Browse all Theses and Dissertations
Evidence shows that a gradient like copolymer can be synthesized using nucleophilic aromatic substitution, NAS, chemistry. Using the 4-chloro-3-fluoro-4'hydroxydiphenylsulfone monomer, 5, it is possible to control the ratios of the leaving groups, in this case the fluorine and the chlorine, with the right solvent and temperature. Alternating the temperatures will alter the substitution of the leaving groups, thus forming a polymer backbone of gradient characteristics. Initial reactions to determine the relative rates of displacement of the chlorine and fluorine atoms were carried out using a model compound, 1, which possessed the chlorine and fluorine leaving groups, but not the phenol …
The Synthesis And Characterization Of Imidazolium Lithium Phthalocyanines, John J. Kelley
The Synthesis And Characterization Of Imidazolium Lithium Phthalocyanines, John J. Kelley
Browse all Theses and Dissertations
A series of 1,3-di-substituted-imidazolium lithium phthalocyanines, in which the substituents on the imidazolium nitrogens were combinations of methyl, ethyl, pentyl, hexyl, isopropyl, adamantyl or 2,4,6-trimethylphenyl groups, was synthesized. The cation exchange of a single lithium ion of dilithium phthalocyanine for a 1,3-disubstituted-imidazolium ion was performed by mixing their salts in common organic solvents under ambient conditions. This afforded a number of imidazolium lithium phthalocyanines in moderate yields. They exhibited poor solubility in most solvents. Their composition and purity were initially verified by 1H and 13C-NMR and elemental analysis. The 1H-NMR spectra also indicated that the imidazolium and lithium phthalocyanine ions …
Het Acid Based Oligoesters – Tga/Ftir Studies, Thangamani Rajkumar, Chinnaswamy Thangavel Vijayakumar, Palanichamy Sivasamy, Charles A. Wilkie
Het Acid Based Oligoesters – Tga/Ftir Studies, Thangamani Rajkumar, Chinnaswamy Thangavel Vijayakumar, Palanichamy Sivasamy, Charles A. Wilkie
Chemistry Faculty Research and Publications
One of the important reactive halogenated dicarboxylic acids used in the synthesis of flame retardant unsaturated polyester resins is 1,4,5,6,7,7-hexachlorobicyclo [2.2.1] hept-5-ene-2,3-dicarboxylic acid (HET acid). In the present investigation four different oligoesters are synthesized using HET acid as the diacid component and 1,2-ethane diol, 1,2-propane diol, 1,3-propane diol and 1,4-butane diol as the aliphatic diols. Melt condensation technique in vacuum is used for the synthesis of the oligoesters. The number average molecular weights of the oligoesters are determined using end group analysis. The degree of polymerization is estimated to be 3–5. The structural characterization is done using FTIR and NMR …