Physical Sciences and Mathematics Commons^™

Pyridoxamine Traps Intermediates In Lipid Peroxidation Reactions In Vivo: Evidence On The Role Of Lipids In Chemical Modification Of Protein And Development Of Diabetic Complications, Thomas O. Metz, Nathan L. Alderson, Mark E. Chachich, Suzanne R. Thorpe, John W. Baynes

Faculty Publications

Maillard or browning reactions between reducing sugars and protein lead to formation of advanced glycation end products (AGEs) and are thought to contribute to the pathogenesis of diabetic complications. AGE inhibitors such as aminoguanidine and pyridoxamine (PM) inhibit both the formation of AGEs and development of complications in animal models of diabetes. PM also inhibits the chemical modification of protein by advanced lipoxidation end products (ALEs) during lipid peroxidation reactions in vitro. We show here that several PM adducts, formed in incubations of PM with linoleate and arachidonate in vitro, are also excreted in the urine of PM-treated animals. The …

Bis[Μ-1,2-Bis(2-Pyridyl)Ethyne-K2N:N']Bis[Aquadinitratocadmium(Ii)], Badruz Zaman Md., Matthew J. Davis, Mark D. Smith, Hans Conrad Zur Loye

Faculty Publications

Two twisted 1,2-bis(2-pyridyl)ethyne ligands bridge two Cd²⁺ centers in the C₂-symmetric title complex, [Cd₂(NO₃)₄(-C₁₂H₈N₂)₂(H₂O)₂]. The bridging ligands arch across one another creating a `zigzag loop' molecular geometry. Two nitrate ions and a water molecule complete the irregular seven-coordinate Cd-atom environment. The dihedral angles between the equivalent pyridyl ring planes of the two independent ligands are 67.2 (1)°. O_water-HO_nitrate hydrogen bonding creates two-dimensional layers parallel to the ab plane.

Formula: [Cd₂(NO₃)₄(C …

Regulation And Localization Of Endogenous Human Tristetraprolin, Anna-Marie Fairhurst, John E. Connolly, Katharine A Hintz, Nicolas J Goulding

Dartmouth Scholarship

Tumor necrosis factor (TNF) has been implicated in the development and pathogenicity of infectious diseases and autoimmune disorders, such as septic shock and arthritis. The zinc-finger protein tristetraprolin (TTP) has been identified as a major regulator of TNF biosynthesis. To define its intracellular location and examine its regulation of TNF, a quantitive intracellular staining assay specific for TTP was developed. We establish for the first time that in peripheral blood leukocytes, express

Asymmetric Transfer Hydrogenation Of Allylic Alcohols, Joseph M. Laquidara

Seton Hall University Dissertations and Theses (ETDs)

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Sr3Mgpto6, Mark D. Smith, Hans Conrad Zur Loye

Faculty Publications

Single crystals of the mixed alkaline earth platinate, tristrontium magnesium platinum hexaoxide, Sr₃MgPtO₆, were grown from a KOH flux at 1273 K. The compound adopts the rhombohedral K₄CdCl₆ structure type, featuring chains of face-shared, distorted MgO₆ trigonal prisms (Mg site symmetry 32) and PtO₆ octahedra (Pt site symmetry ) surrounded by columns of Sr²⁺ ions (Sr site symmetry 2).

Semiclassical Dynamics With Quantum Trajectories: Formulation And Comparison With The Semiclassical Initial Value Representation Propagator, Sophya Garashchuk, Vitaly A. Rassolov

Faculty Publications

We present a time-dependent semiclassical method based on quantum trajectories. Quantum-mechanical effects are described via the quantum potential computed from the wave function density approximated as a linear combination of Gaussian fitting functions. The number of the fitting functions determines the accuracy of the approximate quantum potential (AQP). One Gaussian fit reproduces time-evolution of a Gaussian wave packet in a parabolic potential. The limit of the large number of fitting Gaussians and trajectories gives the full quantum-mechanical result. The method is systematically improvable from classical to fully quantum. The fitting procedure is implemented as a gradient minimization. We also compare …

Investigation Of Model Cell Membrane Disruption Via Fluorescence And Light Scattering Techniques, Imara Charles

Seton Hall University Dissertations and Theses (ETDs)

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