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Full-Text Articles in Physical Sciences and Mathematics
Modification Of Cellular Dna By Synthetic Aziridinomitosenes, Chris M. Mallory, Ryan P. Carfi, Sangphil Moon, Kenneth A. Cornell, Don L. Warner
Modification Of Cellular Dna By Synthetic Aziridinomitosenes, Chris M. Mallory, Ryan P. Carfi, Sangphil Moon, Kenneth A. Cornell, Don L. Warner
Chemistry and Biochemistry Faculty Publications and Presentations
Two synthetic aziridinomitosenes (AZMs), Me-AZM and H-AZM, structurally related to mitomycin C (MC) were evaluated for their anticancer activity against six cancer cell lines (HeLa, Jurkat, T47D, HepG2, HL-60, and HuT-78) and tested for their DNA-modifying abilities in Jurkat cells. Cytotoxicity assays showed that Me-AZM is up to 72-fold and 520-fold more potent than MC and H-AZM, respectively. Me-AZM also demonstrated increased DNA modification over MC and H-AZM in alkaline COMET and Hoechst fluorescence assays that measured crosslinks in cellular DNA. Me-AZM and H-AZM treatment of Jurkat cells was found to sponsor significant DNA-protein crosslinks using …
Life’S Lessons In The Lab: A Summer Of Learning From Undergraduate Research Experiences, Louis S. Nadelson, Don Warner, Eric Brown
Life’S Lessons In The Lab: A Summer Of Learning From Undergraduate Research Experiences, Louis S. Nadelson, Don Warner, Eric Brown
Chemistry and Biochemistry Faculty Publications and Presentations
Research experiences for undergraduates (REUs) seek to increase the participating students’ knowledge and perceptions of scientific research through engagement in laboratory research and related activities. Various REU outcomes have been investigated, including influence on participants’ content knowledge, career plans, and general perceptions of their domains of research. The complexity of REUs and dynamic nature of student development provide opportunity for exploring how REUs influence student growth. Our research focused on first and second-year college students who participated in a residential REU program that took place in a chemistry department in a metropolitan university in the western United States. We assessed …
Excitonic And Logic Gates On Dna Brick Nanobreadboards, Brittany L. Cannon, Donald L. Kellis, Paul H. Davis, Jeunghoon Lee, Wan Kuang, William L. Hughes, Elton Graugnard, Bernard Yurke, William Knowlton
Excitonic And Logic Gates On Dna Brick Nanobreadboards, Brittany L. Cannon, Donald L. Kellis, Paul H. Davis, Jeunghoon Lee, Wan Kuang, William L. Hughes, Elton Graugnard, Bernard Yurke, William Knowlton
Chemistry and Biochemistry Faculty Publications and Presentations
A promising application of DNA self-assembly is the fabrication of chromophore-based excitonic devices. DNA brick assembly is a compelling method for creating programmable nanobreadboards on which chromophores may be rapidly and easily repositioned to prototype new excitonic devices, optimize device operation, and induce reversible switching. Using DNA nanobreadboards, we have demonstrated each of these functions through the construction and operation of two different excitonic AND logic gates. The modularity and high chromophore density achievable via this brick-based approach provide a viable path toward developing information processing and storage systems.