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Full-Text Articles in Physical Sciences and Mathematics
Rnase L Mediates The Insulin Signalling Pathway, Oroshay Kaiwan, Danting Liu
Rnase L Mediates The Insulin Signalling Pathway, Oroshay Kaiwan, Danting Liu
Undergraduate Research Posters 2017
Diabetes is characterized by hyperglycemia mainly due to defect in insulin secretion and/or action. Regulation of glucose transport and use by insulin is central to the maintenance of whole-body glucose homeostasis. One of the potential mechanisms associated with insulin sensitivity is the activation of insulin receptor (IR) and subsequently transduces the signal through phosphorylation of insulin receptor substrate1 (IRS1) and activation of the PI-3K/Akt pathway. RNase L, an interferon (IFN)-inducible enzyme, plays an important role in IFN functions against viral infection and cell proliferation. However, a direct link between RNase L and insulin sensitivity has yet to be clearly established. …
Identification Of Selective Anti-Trypanosome Agents From Compound Library Lopac, Cody M. Orahoske, Myah S. Marbury
Identification Of Selective Anti-Trypanosome Agents From Compound Library Lopac, Cody M. Orahoske, Myah S. Marbury
Undergraduate Research Posters 2017
Sleeping sickness disease (human African trypanosomiasis) is still a major health threat to a large number of people in 36 countries of sub-Saharan Africa. Currently, the estimated infection cases in these areas are between 300,000 and 500,000. Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense are the pathogens of sleeping sickness in humans. These parasites live and proliferate mainly in the blood and tissue fluids of the infected mammals and are transmitted by tsetse flies (Glossina spp.). The disease starts from a bite by an infected tsetse fly and goes through an initial stage, where trypanosomes multiply in the bloodstream and …
Synthesis Of Sialic Acid Derivatives And Their Immune Cells Modulation, Joseph Keil, Lei Yuan, Yu Zhao
Synthesis Of Sialic Acid Derivatives And Their Immune Cells Modulation, Joseph Keil, Lei Yuan, Yu Zhao
Undergraduate Research Posters 2017
The exterior cell surfaces of macrophages express a dense layer of glycans which are often terminated by sialic acid. Sialic acid is an acidic monosaccharide whose presence on the terminal ends of glycans affects cellular function and properties. In particular, due to its hydrophilic and electronegative features, SAs play important roles in both physiological and pathological processes, such as in regulating cellular interactions with ligands, microbes and neighboring cells and in controlling cellular activation, differentiation, transformation and migration. In this study two sialic acid derivatives were synthesized and characterized, the 5 amine derivative and the 9 amine derivative. This study …
Exploration Of Nanomaterials-Based Electrochemical Sensors For Peroxynitrite Detection, Ousama Al-Mahmoud, Haitham Kalil
Exploration Of Nanomaterials-Based Electrochemical Sensors For Peroxynitrite Detection, Ousama Al-Mahmoud, Haitham Kalil
Undergraduate Research Posters 2017
Peroxynitrite (PON, ONOO-) plays an essential role in several cardiovascular dysfunctions and other diseases triggered by oxidative stress. The precise detection of this analyte in biological systems is of paramount importance not only to understand the genesis and development of diseases, but also to design and assess efficient therapies. We fabricated highly sensitive and selective electrochemical sensors based on transition metal-decorated graphene nanocomposites as catalytic interfaces for peroxynitrite quantification. The interfaces of metal-decorated graphene nanostructures were immobilized on carbon electrodes by electro-grafting, electro- depositing, and drop-casting techniques. The morphology and surface chemistry of the nanostructured materials were characterized using Scanning …
P1: Salt Concentration And Ph Affect The Size Of Elastin-Like Polypeptide Nanoparticles, Bryce Noe, Ilona Tsuper, Daniel Terano, Richard Schmitt
P1: Salt Concentration And Ph Affect The Size Of Elastin-Like Polypeptide Nanoparticles, Bryce Noe, Ilona Tsuper, Daniel Terano, Richard Schmitt
Undergraduate Research Posters 2017
The transport of therapeutic drugs to specific tissues in the body can be accomplished using nanoparticles that encapsulate the drugs. Elastin-like polypeptides (ELP) is a class of materials that can reversibly form such nanoparticles in response to environmental cues. FLPs transition from soluble compounds to a phase separated system under particular solution conditions and have been used to produce temperature responsive surfactants. When these ELP surfactants are above their transition temperature, they spontaneously form energetically stable spherical micelles. When the temperature drops below the transition temperature, the micelles break apart and the ELP goes into solution. The size of these …
Evaluation Of Cetane Values Of Glycerolipids Extracted From Algae Scenedesmus Dimorphus Grown In Various Salinity Concentrations Using Gas Chromatography And Mass Spectrometry (Gc-Ms), Paul Lin, Chandana Mannem
Evaluation Of Cetane Values Of Glycerolipids Extracted From Algae Scenedesmus Dimorphus Grown In Various Salinity Concentrations Using Gas Chromatography And Mass Spectrometry (Gc-Ms), Paul Lin, Chandana Mannem
Undergraduate Research Posters 2017
Algae's ability to store lipids, renewability, and potentially safer for the environment has made it a promising alternative fuel source. An industry rating for a biofuel's potential is the cetane value, which is a measure of a fuel's quality related to various glycerolipid concentrations. Growing conditions will affect lipid profile in algae, thereby affecting the cetane value. This project will attempt to identify changes in the centane value of the algae Scenedesmus dimorphus grown in various salinity concentrations. Scenedesmus dimorphus is the algae chosen for this experiment because of its ability to rapidly grow under harsh conditions. In this experiment …
P2: Light Scattering Study Of The Size And Shape Of Mixed Elastin-Like Polypeptide Micelles, Ilona Tsuper, Daniel Terrano, Bryce Noe
P2: Light Scattering Study Of The Size And Shape Of Mixed Elastin-Like Polypeptide Micelles, Ilona Tsuper, Daniel Terrano, Bryce Noe
Undergraduate Research Posters 2017
Elastin-Like Polypeptides (ELP) can be used to form thermoreversible vehicles for drug delivery systems. The ELP nanoparticles are composed of three-armed star polypeptides. Each of the three arms extending from the negatively charged foldon domain include 20 repeats of the (GVGVP) amino acid sequence. In addition, linear constructs composed of 40 repeats of the same (GVGVP) sequence are introduced into the system. The mixed ELP polymer system is soluble at room temperature and becomes insoluble at the transition temperature (~ 50°C) forming micelles with the foldons on the exterior and linear constructs at the core. Above the transition, the size …
P1: Using Modified Dean Flow Designs To Increase Mixing Performance, Joshua Clark
P1: Using Modified Dean Flow Designs To Increase Mixing Performance, Joshua Clark
Undergraduate Research Posters 2017
We are using numerical solutions for the Navier-Stokes equations and the concentration - diffusion equation to model fluid flow and reactant distribution in serpentine type channels for micromixers/microreactors development. These mixers exploit centripetal forces on the fluid to induce cross-sectional fluid mixing, aka Dean flows. Various modifications are used to increase the mixing character of these crosssectional flows. We found that the performance of these mixers exceeds that of unmodified channels and we currently assess their performance relative to other state of the art methodologies used to induce mixing on the microscale.
Going Green: Experimental Adaptation Of Scenedesmus Dimorphus To Marine Conditions, Mohammed Khalil
Going Green: Experimental Adaptation Of Scenedesmus Dimorphus To Marine Conditions, Mohammed Khalil
Undergraduate Research Posters 2017
Algae has gained some interest as the need for alternative fuels becomes more pressing. Reliance on fossil fuels is causing our environment and economy harm, and is not sustainable moving forward. Lipid rich algae strains can be used in the production of biofuels, and provide an alternative fuel source. One challenge facing the prospect of algae as a fuel source is that lipid rich algae grows exclusively in freshwater. Considering the scarcity and cost to use freshwater for algae growth, interest has grown in the possibility of adapting lipid rich, freshwater algae to a seawater environment. Seawater can have up …
P2: Implementation Of Groove Based Designs For Engineering Fluid Flow In Micromixers, Tahir Butt
P2: Implementation Of Groove Based Designs For Engineering Fluid Flow In Micromixers, Tahir Butt
Undergraduate Research Posters 2017
Mixing on microscale is important for the development of miniaturized chemical reactors that use small quantities of reactants and allow better control over the reaction conditions and products. Nevertheless, achieving rapid mixing in this type of micro-reactors is challenging due to the lack of turbulence and slow diffusion on the microscale. In this work we implement micromixers designs based on surface groove/ridge patterns targeted at inducing cross-sectional flows that both extend the interface between the different reactants, as well as induce chaotic advection. We discuss the fabrication of these structures using soft-lithography in PDMS employing a mold and their optical …