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Cyclization Of Peptide Structures By Creating Metal Foldamers Using 99m-Tc/Re(Co)3, Dhvani D. Oza

Electronic Thesis and Dissertation Repository

Constrained peptides have been successful as therapeutics owing to the rigidity in their framework, allowing them to have enhanced pharmacological properties. Apart from covalent bond based cyclization, constraints can be induced by cyclization using metal coordination. The metals Re and ^99mTc are one of the few metals which have not been studied in great detail for their ability to cyclize linear peptides. A tri-alanine sequence was employed in the peptide backbone due to its ability to form stable helices. In addition, another tripeptide sequence RGD, which is recognized by the integrin a_vb₃, was also used. …