Physical Sciences and Mathematics Commons^™

Developing Structure-Activity-Relationships For Metal-Ligand-Cooperative (Mlc) Complexes Using Pr2nr′2 Ligands, James M. Stubbs

Electronic Thesis and Dissertation Repository

Exploring efficient and environmentally-friendly routes to synthesize molecules is critical for the pharmaceutical and fine chemical industries. One method is to study current catalytic methods to increase selectivity and performance for challenging reactions. Inclusion of an intramolecular acid/base site on the ligand manifold of an organometallic complex has allowed for new mechanistic pathways and enhanced reactivity. This thesis delves into understanding organometallic complexes in catalysis by systematic tuning the ligand properties. Synthesis of P^R₂N^R′₂ ligands was performed to enable the systematic tuning as R and R′ alter the electronic and steric properties of the primary …