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- Amino-acid transporter; cell-growth; aspartate transporter; molecular simulation; glutamine transport; anion conductance; tumor-development; substrate;cancer; benchmarking (1)
- Cancer-cell proliferation; transmembrane helix; extracellular ph; tumor microenvironment; lipid-membranes; drug-delivery; neck-cancer; phlip; translocation; NMR (1)
- Indium-phosphide nanowires; electrical-properties; contact resistance;carbon nanotubes; semiconductor nanowires; ohmic contacts; inp nanowires; devices;nanomaterials; electrodes (1)
Articles 1 - 4 of 4
Full-Text Articles in Physical Sciences and Mathematics
Ligand Discovery For The Alanine-Serine-Cysteine Transporter (Asct2, Slc1a5) From Homology Modeling And Virtual Screening, Colas Claire, Christof Grewer, Nicholas J. Otte, Armanda Gameiro, Thomas Albers, Kurnvir Singh, Helen Shere, Massimiliano Bonomi, Jeff Holst, Avner Schlessinger
Ligand Discovery For The Alanine-Serine-Cysteine Transporter (Asct2, Slc1a5) From Homology Modeling And Virtual Screening, Colas Claire, Christof Grewer, Nicholas J. Otte, Armanda Gameiro, Thomas Albers, Kurnvir Singh, Helen Shere, Massimiliano Bonomi, Jeff Holst, Avner Schlessinger
Chemistry Faculty Scholarship
The Alanine-Serine-Cysteine transporter ASCT2 (SLC1A5) is a membrane protein that transports neutral amino acids into cells in exchange for outward movement of intracellular amino acids. ASCT2 is highly expressed in peripheral tissues such as the lung and intestines where it contributes to the homeostasis of intracellular concentrations of neutral amino acids. ASCT2 also plays an important role in the development of a variety of cancers such as melanoma by transporting amino acid nutrients such as glutamine into the proliferating tumors. Therefore, ASCT2 is a key drug target with potentially great pharmacological importance. Here, we identify seven ASCT2 ligands by computational …
Nanoscale Alloying In Electrocatalysts, Shiyao Shan, Jinfang F. Wu, Ning Kang, Hannah Cronk, Yinguang G. Zhao, Wei Zhao, Zakiya Skeete, Joseph Pharrah, Bryan Trimm, Jin Luo, Chuan-Jian Zhong
Nanoscale Alloying In Electrocatalysts, Shiyao Shan, Jinfang F. Wu, Ning Kang, Hannah Cronk, Yinguang G. Zhao, Wei Zhao, Zakiya Skeete, Joseph Pharrah, Bryan Trimm, Jin Luo, Chuan-Jian Zhong
Chemistry Faculty Scholarship
In electrochemical energy conversion and storage, existing catalysts often contain a high percentage of noble metals such as Pt and Pd. In order to develop low-cost electrocatalysts, one of the effective strategies involves alloying noble metals with other transition metals. This strategy promises not only significant reduction of noble metals but also the tunability for enhanced catalytic activity and stability in comparison with conventional catalysts. In this report, some of the recent approaches to developing alloy catalysts for electrocatalytic oxygen reduction reaction in fuel cells will be highlighted. Selected examples will be also discussed to highlight insights into the structural …
Nanocontact Disorder In Nanoelectronics For Modulation Of Light And Gas Sensitivities, Yen-Fu Lin, Chia-Hung Chang, Tsu-Chang Hung, Wen-Bin Jian, Kazuhito Tsukagoshi, Yue-Han Wu, Li Chang, Zhaoping Liu, Jiye Fang
Nanocontact Disorder In Nanoelectronics For Modulation Of Light And Gas Sensitivities, Yen-Fu Lin, Chia-Hung Chang, Tsu-Chang Hung, Wen-Bin Jian, Kazuhito Tsukagoshi, Yue-Han Wu, Li Chang, Zhaoping Liu, Jiye Fang
Chemistry Faculty Scholarship
To fabricate reliable nanoelectronics, whether by top-down or bottom-up processes, it is necessary to study the electrical properties of nanocontacts. The effect of nanocontact disorder on device properties has been discussed but not quantitatively studied. Here, by carefully analyzing the temperature dependence of device electrical characteristics and by inspecting them with a microscope, we investigated the Schottky contact and Mott's variable-range-hopping resistances connected in parallel in the nanocontact. To interpret these parallel resistances, we proposed a model of Ti/TiOx in the interface between the metal electrodes and nanowires. The hopping resistance as well as the nanocontact disorder dominated the total …
Residue-Specific Structures And Membrane Locations Of Ph-Low Insertion Peptide By Solid-State Nuclear Magnetic Resonance, Nicolas S. Shu, Michael S. Chung, Lan L. Yao, Ming An, Wei Qiang
Residue-Specific Structures And Membrane Locations Of Ph-Low Insertion Peptide By Solid-State Nuclear Magnetic Resonance, Nicolas S. Shu, Michael S. Chung, Lan L. Yao, Ming An, Wei Qiang
Chemistry Faculty Scholarship
The pH-low insertion peptide (pHLIP) binds to a membrane at pH 7.4 unstructured but folds across the bilayer as a transmembrane helix at pH similar to 6. Despite their promising applications as imaging probes and drug carriers that target cancer cells for cytoplasmic cargo delivery, the mechanism of pH modulation on pHLIP-membrane interactions has not been completely understood. Here, we show the first study on membrane-associated pHLIP using solid-state NMR spectroscopy. Data on residue-specific conformation and membrane location describe pHLIP in various surface-bound and membrane-inserted states at pH 7.4, 6.4 and 5.3. The critical membrane-adsorbed state is more complex than …