Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Physical Sciences and Mathematics
Pharmaflights: Fragment Based Drug Discovery Based On Chalcones With A 3,4,5-Trimethoxy Substitution On Ring B., Cody Fourman
Pharmaflights: Fragment Based Drug Discovery Based On Chalcones With A 3,4,5-Trimethoxy Substitution On Ring B., Cody Fourman
The University Honors Program
The 3,4,5-trimethoxyphenyl motif is a common structural feature of a number of natural occurring antimitotic agents, especially those capable interacting with microtubules such as the cis-stilbene, combrestatin A-4. Chalcones possessing this pharmacophore have likewise been demonstrated to exhibit a diverse range of biological actions including anticancer, anti-invasive, antioxidant, and anti-inflammatory activities. As part of an experiential learning experience in academic drug discovery termed WSU PharmaFlights, so-called flights of 6-10 molecules based on a particular biologically relevant structural pattern on the privileged chalcone scaffold are to be designed, synthesized, and spectroscopically characterized as a starting point for lead-development with potential biological …
Chlorination Of 3-Arylsydnones With Iodine Monochloride, Ben Owens
Chlorination Of 3-Arylsydnones With Iodine Monochloride, Ben Owens
The University Honors Program
An improved method for the chlorination at the 4-position of 3- arylsydnones 1 was developed, using iodine monochloride (ICl) dissolved in DCM. 1,3,4-Oxadiazol-2(3H)-ones 3 were then synthesized from the resultant 4-chloro-3-arylsydnones 2. The scope and limitations will be presented.