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Full-Text Articles in Physical Sciences and Mathematics
Mutating Lpar4 In The Visual System Using Crispr, Thomas A. Gonzalez
Mutating Lpar4 In The Visual System Using Crispr, Thomas A. Gonzalez
S.U.R.E Posters
The visual system is developed throughout the embryonic stage and is dictated by axon guidance molecules that tell the growing fibers of nerve cells, axons, where to grow. The ends of axons, called growth cones, continuously sprout out or collapse based on the axon guidance molecules. Research has shown that lysophosphatidic acid (LPA) causes growth cone collapse, so it is hypothesized that it is an axon guidance molecule. LPA binds to specific receptors, known as Lpars of which there are at least five known. Previous research indicates that Lpar 1,2, and 3 are not required in mice for growth cone …
Discovery Research For New Optical Materials, Kameron Johnson
Discovery Research For New Optical Materials, Kameron Johnson
S.U.R.E Posters
This project utilizes the MGI approach in order to discover new compounds at an accelerated rate. Novel materials for optical applications, such as luminescent scintillators, are desired for improvement of properties. Using density functional theory (DFT) calculations, new single-crystal scintillating materials can be optimized leading to more efficient scintillation. (5) Two existing compounds in the quaternary system Na-O-Si-Y were chosen and further modified using substitutions into proposed structures that can be investigated. The two original compounds, NaO4SiY and NaO26Si6Y9, were chosen and modified because of their already high density by substituting yttrium for lanthanum, sodium for potassium and yttrium for …
Elucidating The Effect Of The Antibiotic Tetracycline On The Regulatory Function Of The Guanidine Sensing Riboswitch Ykkcd, Thomas K. Sullivan
Elucidating The Effect Of The Antibiotic Tetracycline On The Regulatory Function Of The Guanidine Sensing Riboswitch Ykkcd, Thomas K. Sullivan
S.U.R.E Posters
The primary objective of this research is to develop an assay – one more feasible for undergraduate institutions than currently available methods – that will enable evaluation of the concomitant binding of, guanidine and tetracycline to the ykkCD bacterial guanidine sensor riboswitch. This noncoding regulatory RNA, in addition to guanidine, also recognizes tetracycline, a translation-inhibiting antibiotic, via a high-affinity aptamer domain. The resulting conformational change by the riboswitch upregulates the expression of genes that are downstream of this regulator, most of which are membrane transporter that expel toxins from bacteria. This phenomenon exemplifies the increasing issue of bacterial antibiotic resistance, …
Photoredox Mediated Alkylation Of Imines With Potassium Organotrifluoroborates In The Presence Of An Organic Photocatalyst, Jackson W. Barrett, Evan H. Thibodeaux, Molly A. Quetel, Eric J. Walters
Photoredox Mediated Alkylation Of Imines With Potassium Organotrifluoroborates In The Presence Of An Organic Photocatalyst, Jackson W. Barrett, Evan H. Thibodeaux, Molly A. Quetel, Eric J. Walters
S.U.R.E Posters
Our group is investigating the application of an organic photocatalyst, 9-mesityl-10-methyl acridinium tetrafluoroborate (Mes-Acr-Me), to the alkylation of aryl imines with potassium organotrifluoroborates. In the past, our group has employed an potassium isopropyltrifluoroborate for model reactions, but we desired to expand our BF3K scope to see the effects of variation in the alkyl group of the organotetrafluoroborate. In addition, we also wanted to study the substituent electronic effects in the imine, which was done using a series of competition experiments.
Using Nucleic Acid-Gold Nanoparticle Conjugate In The Fight Against Bacteria That Are Resistant To Tetracycline Antibiotics, Allen T. Livingston
Using Nucleic Acid-Gold Nanoparticle Conjugate In The Fight Against Bacteria That Are Resistant To Tetracycline Antibiotics, Allen T. Livingston
S.U.R.E Posters
Antibiotic resistance is major problem in modern medicine. Seventy percent of bacterial strains are resistant to at least one antibiotic, making treatment of bacterial infections ever more expensive and difficult. Currently, we are investigating the therapeutic potency of nucleic acid-gold nanoparticle conjugates as treatments against bacteria that are resistant to the antibiotic tetracycline. We hypothesize that by attaching RNA that binds to tetracycline to silver or gold nanoparticles the resulting conjugates will work as a “Trojan-horse” tetracycline-delivery vehicle that smuggles the antibiotic into the cell without being detected by cellular defense systems. Moreover, we reason that silver or gold ions …