Physical Sciences and Mathematics Commons^™

Genomic Instability Induced By Two Chemical Carcinogens, Cadmium And Nickel And By Particulate Titanium Debris From An Implant, Natasha Coen

Doctoral

It has been established that cells surviving radiation may produce descendants many cell divisions post-exposure in which, there are high incidences of chromosomal aberrations arising de novo, gene mutation and lethal mutations/delayed cell death. These effects are collectively known as genomic instability and are induced at frequencies greater than that of spontaneous mutations. Formally this syndrome ‘genomic instability’ has only been definitively proven to occur following irradiation. This leads us to the consideration that heavy metals could also induce the genomic instability phenotype, and if so, it could have implications for those exposed through their occupation, through smoking or for …