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Ram S. Mohan

Bismuth and compounds; Carbonyl-ene reaction; Cyclizations; Lewis acids.

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Environment Friendly Organic Synthesis Using Bismuth Compounds. An Efficient Method For Carbonyl-Ene Reactions Catalyzed By Bismuth Triflate, Ram S. Mohan, Erin D. Anderson, Justin J. Ernat, Mai P. Nguyen, Ann C. Palma Dec 2004

Environment Friendly Organic Synthesis Using Bismuth Compounds. An Efficient Method For Carbonyl-Ene Reactions Catalyzed By Bismuth Triflate, Ram S. Mohan, Erin D. Anderson, Justin J. Ernat, Mai P. Nguyen, Ann C. Palma

Ram S. Mohan

Bismuth triflate (0.1 mol %) is a highly efficient catalyst for the cyclization of citronellal 1, a reaction that yields a ratio of 80:20 of isopulegol 2 and neoisopulegol 3. This methodology has also been extended to the synthesis of substituted piperidines. The bismuth triflate catalyzed ene reaction of aldehyde 4 gives a 70:30 mixture of piperidines 5 and 6. The advantages of these methods include the use of a highly efficient catalyst that is relatively nontoxic, cheap and easy to handle.

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