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Full-Text Articles in Physical Sciences and Mathematics
Nontargeted Comprehensive Two-Dimensional Gas Chromatography/Time-Of-Flight Mass Spectrometry Method And Software For Inventorying Persistent And Bioaccumulative Contaminants In Marine Environments, Eunha Hoh, Nathan G. Dodder, Steven J. Lehotay, Kristin C. Pangallo, Christopher M. Reddy, Keith A. Maruya
Nontargeted Comprehensive Two-Dimensional Gas Chromatography/Time-Of-Flight Mass Spectrometry Method And Software For Inventorying Persistent And Bioaccumulative Contaminants In Marine Environments, Eunha Hoh, Nathan G. Dodder, Steven J. Lehotay, Kristin C. Pangallo, Christopher M. Reddy, Keith A. Maruya
Kristin Pangallo
Analytical methods for contaminant monitoring are generally targeted; i.e., they measure defined lists of compounds. Routine monitoring projects using targeted methods are not usually designed to screen for unrecognized or novel contaminants, and therefore miss compounds within the region or population of study that cause, or have the potential to cause, adverse biological impacts. We describe a non-targeted analytical method utilizing direct sample introduction (DSI) coupled to comprehensive two-dimensional gas chromatography with time-offlight mass spectrometry (GC×GC/TOF-MS). To test the capabilities of this instrumental method within the context of marine contaminant surveys, we characterized a broad array of non-polar, persistent and …