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Full-Text Articles in Physical Sciences and Mathematics
Printing 3d Models For Chemistry: A Step-By-Step Open-Source Guide For Hobbyists, Corporate Professionals, And Educators And Students In K-12 And Higher Education, Elisabeth Grace Billman-Benveniste, Jacob Franz, Loredana Valenzano-Slough
Printing 3d Models For Chemistry: A Step-By-Step Open-Source Guide For Hobbyists, Corporate Professionals, And Educators And Students In K-12 And Higher Education, Elisabeth Grace Billman-Benveniste, Jacob Franz, Loredana Valenzano-Slough
Open Access Books
3D-printing is a relatively inexpensive additive manufacturing method used to create tangible objects. As a relatively new technology, the true capability of 3D-printing has not yet been fully exploited, especially in academic and research/teaching settings. Through this work, 3D-printing in a classroom and research environment is employed as a tool for creation of fully customizable, three-dimensional molecular models and for the visualization of theoretical abstract concepts.
Computational Chemical Biology: From Atomistic Insights Towards Drug Design, Christo Christov
Computational Chemical Biology: From Atomistic Insights Towards Drug Design, Christo Christov
TechTalks
No abstract provided.
Fluorescent Conjugated Polymers With A Bodipy-Based Backbone And Uses Thereof, Haiying Liu
Fluorescent Conjugated Polymers With A Bodipy-Based Backbone And Uses Thereof, Haiying Liu
Michigan Tech Patents
The present invention provides various fluorescent conjugated polymers with a BODIPY-based backbone. The invention also provides methods of using the polymers of the invention, such as for imaging and detection of cells, tumors, bacteria and viruses.
Understanding The Role Of Protein Misfolding In Neurodegenerative Diseases, Ashutosh Tiwari
Understanding The Role Of Protein Misfolding In Neurodegenerative Diseases, Ashutosh Tiwari
TechTalks
Protein aggregates are hallmark of several age related disorders including neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Alzheimer’s and Parkinson’s disease. However, the underlying mechanisms by which these aggregated proteins impair cellular functions and cause toxicity is not clear. I will discuss efforts from my laboratory to characterize these misfolded and aggregated protein structures and their associated toxicity.
Designing Proteins For Biomechanical And Molecular Biological Studies, Momoko Tajiri
Designing Proteins For Biomechanical And Molecular Biological Studies, Momoko Tajiri
TechTalks
Proteins are large biomolecules consisting one or more long chain of amino acid residues. Proteins perform a wide variety of functions within organisms including catalyzing metabolic activities, signal transduction, and transportation of molecules. They function differently from one another as their sequences of amino acids and also due to a variation of modification placed on residues. Change in modification patterns will impact protein interaction with other molecules, thus influence normal cell activities and may lead to disease development. In order to study the consequences of modification, we have a method to prepare proteins with desired modification patterns. Using the technique, …
Molecules, Surfaces, Crystals: A Quantum Chemical Quest From Fundamentals To Applications, Loredana Valenzano
Molecules, Surfaces, Crystals: A Quantum Chemical Quest From Fundamentals To Applications, Loredana Valenzano
TechTalks
My research focuses on applying fundamental laws governing the behavior of molecules and materials to predict their real-world performance. Using state-of-the-art quantum chemical approaches as my tool set, I computationally model a wide range of molecular and condensed-matter systems: explosives, pharmaceuticals, porous materials, catalysts, nanomaterials, polymers, soft-matter, films, membranes, surfaces, interfaces, layered materials; hybrid systems: molecules interacting with substrates; and, their properties: structural, energetic, vibrational, electronic, mechanical, adsorption, diffusion. Chemical processes such as reactivity and the change of properties after exposure to external agents (e.g. durability) can also be explored. The results of my investigations can contribute to speeding up, …
Introducing The New 2d-Liquid Chromatograph And High-Resolution Mass Spectrometer In The Chemical Advanced Resolution Methods (Charm) Core Facility At Michigan Tech, Lynn Mazzoleni
TechTalks
A Thermo Scientific Orbitrap Elite Mass Spectrometer (high-resolution Orbitrap Elite MS) and a Dionex UltiMate 3000 two-dimensional liquid chromatographic (2d LC) system were recently acquired. The Orbitrap Elite MS is a hybrid instrument, which includes a dual pressure linear ion trap MS and a compact high-field Orbitrap MS. The instrument design enables high-quality, fast MSn characterization with ultrahigh resolution measurements (R = 240,000 at m/z 400) for mass measurements with less than 1 ppm mass error. Therefore, the instrument has the qualitative capability to identify molecular formulas and structure and, when paired with modern chromatography, provides quantitative assessment of analytes. …
Enriching Health-Related Research Through Glycobiological Approaches, Tarun K. Dam
Enriching Health-Related Research Through Glycobiological Approaches, Tarun K. Dam
TechTalks
In the Laboratory of Mechanistic Glycobiology at Michigan Technological University, we have been working in four distinct but related areas. Our findings can significantly influence human health-related research. (1) We have documented a molecular strategy that can improve drug designing. (2) We have shown that the tumor-associated protein galectin-3 can create problems in cancer biomarker assays by hiding the biomarkers. (3) In another project, we reported that the role of galectin-3 in cancer could be more complicated than what is reported in the literature. (4) Our team also detected a novel natural product with anti-fungal and anti-cancer activities.
Fluorescent Conjugated Polymers With A Bodipy-Based Backbone And Uses Thereof, Haiying Liu
Fluorescent Conjugated Polymers With A Bodipy-Based Backbone And Uses Thereof, Haiying Liu
Michigan Tech Patents
The present invention provides various fluorescent conjugated polymers with a BODIPY-based backbone. The invention also provides methods of using the polymers of the invention, such as for imaging and detection of cells, tumors, bacteria and viruses.
Purification Of Synthetic Oligonucleotides, Shiyue Fang
Purification Of Synthetic Oligonucleotides, Shiyue Fang
Michigan Tech Patents
This invention provides a method for purifying synthetic oligonucleotides comprising capping, polymerizing and separating any failure sequences produced during oligonucleotide synthesis. The invention also provides a method for purifying synthetic oligonucleotides comprising reacting a full length oligonucleotide with a compound to attach a polymerizable functional group to an end of the full length oligonucleotide, polymerizing the full length oligonucleotides and removing the failure sequences, and recovering the full length oligonucleotides. The invention also provides novel capping agents having a polymerizable functional group, and kits comprising at least one composition of the present invention.
Anti-Icing Coatings And Methods, Russell G. Alger
Anti-Icing Coatings And Methods, Russell G. Alger
Michigan Tech Patents
A method of inhibiting or preventing bonding between snow or ice and a substrate. The method includes applying an adhesive to the substrate, broadcasting an aggregate onto the adhesive, the aggregate having the capacity to receive an anti-icing chemical into the aggregate, and applying the anti-icing chemical onto the aggregate so that at least a portion of the anti-icing chemical is received into at least a portion of the aggregate.