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Chemistry And Biochemistry News, Georgia Southern University

Department of Chemistry and Biochemistry News (2015-2023)

• Faculty members from Chemistry and Biology Department Recived a Sustainability Fee Grant
• Teaching Scholarship

• CEMITURE 2015- Research Experience for Undergraduates

Controllable And Switchable Drug Delivery Of Ibuprofen From Temperature Responsive Composite Nanofibers, Toan Tran, Mariana Hernandez, Dhruvil Patel, Elena Burns, Vanessa Peterman, Ji Wu

Department of Chemistry and Biochemistry Faculty Publications

Composited electrospun nanofibers made of temperature-responsive poly(N-isopropylacrylamide) (pNIPAM) and biodegradable poly (ε-caprolactone) (PCL) can be utilized for ‘on-demand’ and controlled drug release of ibuprofen without burst effect for potential pharmaceutical applications. Three types of nanofibers, PCL, pNIPAM and pNIPAM/PCL composite NFs containing ibuprofen were fabricated using electrospinning techniques. Ibuprofen release rates from PCL NFs are not affected by the temperature in the range of 22–34°C (less than 10%). In contrast, the ibuprofen release rates from pNIPAM NFs are very sensitive to the change in temperature, which is five times higher at 22°C compared to 34°C. However, there is a serious …

Chemistry And Biochemistry News, Georgia Southern University

Department of Chemistry and Biochemistry News (2015-2023)

• Graduation Weekend

Chemistry And Biochemistry News, Georgia Southern University

Department of Chemistry and Biochemistry News (2015-2023)

• Chemistry Students Make a Splash at GSU Research Symposium

Chemistry And Biochemistry News, Georgia Southern University

Department of Chemistry and Biochemistry News (2015-2023)

• Eagles Fly to Denver for Chemistry Presentations

Chemistry And Biochemistry News, Georgia Southern University

Department of Chemistry and Biochemistry News (2015-2023)

• Faculty Highlight: Ji Wu

Chemistry And Biochemistry News, Georgia Southern University

Department of Chemistry and Biochemistry News (2015-2023)

• Faculty Highlight: John Stone

Temperature And Ph Responsive Microfibers For Controllable And Variable Ibuprofen Delivery, Toan Tran, Mariana Hernandez, Dhruvil Patel, Ji Wu

Department of Chemistry and Biochemistry Faculty Publications

Electrospun microfibers (MFs) composed of pH and temperature responsive polymers can be used for controllable and variable delivery of ibuprofen. First, electrospinning technique was employed to prepare poly(ε-caprolactone) (PCL) and poly(N-isopropylacrylamide-co-methacrylic acid) (pNIPAM-co-MAA) MFs containing ibuprofen. It was found that drug release rates from PCL MFs cannot be significantly varied by either temperature (22–40°C) or pH values (1.7–7.4). In contrast, the ibuprofen (IP) diffusion rates from pNIPAM-co-MAA MFs were very sensitive to changes in both temperature and pH. The IP release from pNIPAM-co-MAA MFs was highly linear and controllable when the temperature was above the lower critical solution temperature (LCST) …