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Articles 1 - 28 of 28
Full-Text Articles in Physical Sciences and Mathematics
Investigation Of Electron Transfer In The Ksha-Kshb-R286a Protein Complex From Mycobacterium Tuberculosis, Elyse Tavares
Investigation Of Electron Transfer In The Ksha-Kshb-R286a Protein Complex From Mycobacterium Tuberculosis, Elyse Tavares
Honors Program Theses and Projects
With drug-resistant bacteria such as Mycobacterium tuberculosis being a serious public health problem, infected individuals have minimal treatment options. By investigating the electron transfer within 3-ketosteroid-9��-hydroxylase (KshAB), a protein involved in the energy production pathway of this bacteria, it will allow for potential inhibitors of this enzyme to be designed as antibiotics against tuberculosis. The purpose of this project is to stop the interaction between the KshA and KshB complexes to prevent the bacteria from gaining energy by breaking down steroids like cholesterol. To achieve this goal, an arginine at the 286th position of the KshB protein was mutated to …
An Investigation Into The Use Of Ionic Liquid Solvents As Potential Therapeutic Agents To Help Alleviate Disease Caused By The Formation Of Insoluble Plaque Or Depositions, Sundus Alchaar
Honors Program Theses and Projects
Many diseases are caused or worsened by the formation of insoluble aggregates inside the human body, most of which are currently treated by maintenance medication or surgery. Biocompatible Ionic Liquids (ILs) have been explored for use as therapeutic agents, and are also excellent solvents, due to their versatile physical and chemical properties. The aim of this project was to conduct a preliminary exploration of the use of ILs to dissolve different types of depositions, such as kidney stones and crystal-induced arthropathies, and plaques. An imidazolium-based IL and four biocompatible choline amino acid-based ILs ([Ch][AA]-ILs) were synthesized, which are 1-methyl-3-butyl-methylimidazolium iodide …
Optimizing Photosystem I And Plastocyanin Isolation To Develop A Photosystem I-Catalyst System For Photochemical Hydrogen Production, Angelina Vuong
Optimizing Photosystem I And Plastocyanin Isolation To Develop A Photosystem I-Catalyst System For Photochemical Hydrogen Production, Angelina Vuong
Honors Program Theses and Projects
Over the course of many years, greenhouse gases such as carbon dioxide (CO2) and methane (CH4) have formed in large amounts in the atmosphere, which has contributed to global warming. Global warming can lead to extreme weather conditions or have an impact on living organisms, for example, wildfires, droughts, limited amount of food sources, and respiratory issues from pollution. This is mainly due to the use of burning fossil fuel as an energy source, which emits greenhouse gases into the air and traps heat into the atmosphere. Thus, the aim of this study is to assemble and characterize a system …
Developing An Inquiry-Based Laboratory Project For Chem 142l Course At Bsu, Manuel Pina
Developing An Inquiry-Based Laboratory Project For Chem 142l Course At Bsu, Manuel Pina
Honors Program Theses and Projects
In addition to content knowledge, critical and independent thinking, scientific reasoning, and problem-solving skills are essential in preparing next generation of successful workforce. Since one of the biggest advantages of STEM disciplines is a “must-have” hands-on laboratory experience, it is intuitive to exploit this learning space to reinforce afore-mentioned skills. In this context, project-based (PBL) or inquiry-based (IBL) laboratory experiences are rapidly becoming mainstream pedagogical choice for many STEM instructors across United States.[1-4] PBL, and IBL are learning experiences that offer students an opportunity to experience realistic scientific process of discovery through carefully designed inquiry-driven and/or open-ended investigative laboratory …
Bacteria-Mediated Synthesis Of Cobalt(Ii,Iii) Oxide Nanostructures, Ryan Loughran
Bacteria-Mediated Synthesis Of Cobalt(Ii,Iii) Oxide Nanostructures, Ryan Loughran
Honors Program Theses and Projects
This work describes the synthesis of Co3O4 using rod-shaped Gram-positive bacteria Lactobacillus rhamnosus as a template. The motivation behind this project was to find potentially cheaper and environmentally benign protocols in comparison to the current solution-based methods.
New Innovation In The Flipped Chemistry Classroom
New Innovation In The Flipped Chemistry Classroom
The Graduate Review
No abstract provided.
Synthesis Of Novel Reiii And Rev Metallointercalator Complexes For Use As Dna Damage Probes, Eli Schwartz
Synthesis Of Novel Reiii And Rev Metallointercalator Complexes For Use As Dna Damage Probes, Eli Schwartz
Honors Program Theses and Projects
Cancer is a disease that affects millions around the globe. Treatments such as radiation and chemotherapy are often used to treat cancerous tumors, but are not 100% effective in curing the patient. Alternatively, some research groups have proposed the use of metallointercalators, metal complexes consisting of a rhodium, ruthenium, or iridium metal center with bidentate supporting ligands such as bipyridine and phenanthroline, or tridentate ligands such as terpyridine. The complexes also contain a bidentate intercalating group such as dipyridophenazine. These complexes possess the ability to directly bind to DNA through intercalation between the stacks of DNA base pairs, giving them …
Synthesis Of A Protein Based Photocatalytic Hydrogen Production System, Alexander M. Brown
Synthesis Of A Protein Based Photocatalytic Hydrogen Production System, Alexander M. Brown
Honors Program Theses and Projects
Anthropogenic climate change is one of the most pressing challenges facing humans today. It is scientifically established that the production of copious amounts of greenhouse gases such as carbon dioxide (CO2) is the primarycause of global warming. Many of these greenhouse gases are produced from the combustion of carbon-based fuels and researchers are investigating promising alternative fuel sources such as hydrogen gas. Hydrogen gas is a clean burning fuel that stores a significant amount of chemical potential energy. The goal of this project was to synthesize a protein based photocatalytic hydrogen production system and to characterize the effects of modifications …
Implementation Of Computational Chemistry As Part Of The Physical Chemistry Curriculum, Erica Hess
Implementation Of Computational Chemistry As Part Of The Physical Chemistry Curriculum, Erica Hess
Honors Program Theses and Projects
Physical chemistry is a sub-discipline of chemistry that focuses on the study of matter at the molecular and atomic level. Since physical chemistry provides foundational knowledge necessary to explain concepts ranging from atomic to molecular structure, chemical reactions and dynamics, to spectroscopy properties of chemical and biochemical systems, it has deeper connections to all other sub-fields of chemistry. Therefore, it is imperative for undergraduate students within chemical science baccalaureate degree programs have a comprehensive understanding of physical chemistry concepts. However, many students taking physical chemistry at an undergraduate level often cannot see its inherent connections to other chemistry sub-disciplines. This …
Development Of A High-Throughput Screening Assay For Potential Inhibitors Against Dna Polymerase Eta, Keri Bryson
Development Of A High-Throughput Screening Assay For Potential Inhibitors Against Dna Polymerase Eta, Keri Bryson
Honors Program Theses and Projects
All living cells perform DNA replication through a group of enzymes called DNA polymerases. Unfortunately, DNA is constantly exposed to external and internal agents capable of causing damage. DNA damage causes blocks to replication that can be overcome through a special class of DNA polymerases, called the Y-family polymerases; which are able to traverse DNA lesions. Cisplatin is a common chemotherapeutic agent that damages DNA and has been used to treat cancer. However, many patients become resistant to cisplatin. The chemoresistance to cisplatin treatment is due in part to damage bypass performed by the specific Y-family polymerase, polymerase eta. The …
Kinetic Studies On The Aqueous Chemistry Of The Glutathione-Methyleneoxindole Conjugate To Model Its Inhibition Of Glyoxalase I, Ariane Borges
Kinetic Studies On The Aqueous Chemistry Of The Glutathione-Methyleneoxindole Conjugate To Model Its Inhibition Of Glyoxalase I, Ariane Borges
Honors Program Theses and Projects
Glyoxalase I (GxI) is an enzyme that is part of the Glyoxalase system which is responsible for the conversion of methylglyoxal (MG), a byproduct of glycolysis, to lactic acid using glutathione (GSH) as a co-substrate. Methylglyoxal and GSH come together to form the hemithioacetal substrate, which is then transformed into (S)-D-lactoylglutathione. Since MG is a highly reactive compound known to induce cell apoptosis, increasing MG levels in cells by inhibiting GxI should increase cell death. Research into the design, synthesis and testing of different inhibitors of GxI support this hypothesis. We have designed and synthesized a potential inhibitor of GxI, …
Development Of A Kinetic Model For The Transesterification Of Glycerol Fatty Acid Triesters Using 1H (1d And 2d) Nmr, Leonard W. Sprague
Development Of A Kinetic Model For The Transesterification Of Glycerol Fatty Acid Triesters Using 1H (1d And 2d) Nmr, Leonard W. Sprague
Honors Program Theses and Projects
Fossil fuels dating back to the first coal mine dug from the Earth have been vital to society’s advances, but have come at a significant cost. Rise in pollutants such as CO2 and particulate matter due to combustion byproducts of these fuels (coal, oil, gasoline, diesel) continue to negatively impact the environment, harming various ecosystems by disrupting precarious balances. Attempts have been made to “clean” fossil fuels, but only to temporary degrees of success. Alternative energy sources such as solar, wind, or hydroelectric are increasing in viability, but are often a difficult transition for fossil fuel reliant individuals. Biodiesel (Fatty …
Multi-Frequency Ferromagnetic Resonance Investigation Of Nickel Nanocubes Encapsulated In Diamagnetic Magnesium Oxide Matrix, Saritha Nellutla, Sudhakar Nori, Srinivasa R. Singamaneni, John T. Prater, Jagdish Narayan, Alix I. Smirnov
Multi-Frequency Ferromagnetic Resonance Investigation Of Nickel Nanocubes Encapsulated In Diamagnetic Magnesium Oxide Matrix, Saritha Nellutla, Sudhakar Nori, Srinivasa R. Singamaneni, John T. Prater, Jagdish Narayan, Alix I. Smirnov
Chemical Sciences Faculty Publications
Partially aligned nickel nanocubes were grown epitaxially in a diamagnetic magnesium oxide (MgO:Ni) host and studied by a continuous wave ferromagnetic resonance (FMR) spectroscopy at the X-band (9.5 GHz) from ca. 117 to 458 K and then at room temperature for multiple external magnetic fields/resonant frequencies from 9.5 to 330 GHz. In contrast to conventional magnetic susceptibility studies that provided data on the bulk magnetization, the FMR spectra revealed the presence of three different types of magnetic Ni nanocubes in the sample. Specifically, three different ferromagnetic resonances were observed in the X-band spectra: a line 1 assigned to large nickel …
Applying Green Chemistry Principles In The Electrophilic Bromination Of Indole-3-Acetic Acid, Kyle Murphy
Applying Green Chemistry Principles In The Electrophilic Bromination Of Indole-3-Acetic Acid, Kyle Murphy
Undergraduate Review
The goals of green chemistry are to reduce or eliminate the use of hazardous reagents, prevent the synthesis of toxic products and byproducts, and improve the overall efficiency of chemical reactions. Green chemistry is incredibly important today as chemical products are produced and used around the world, resulting in the use and generation of hazardous chemicals, and unintended consequences to human health and the environment. Figure 1 shows the 12 Principles of Green Chemistry1, developed by Paul Anastas and John Warner, which provide the framework for a sustainable future in the design of more efficient technologies to produce consumer products …
Research Brief: Applying Green Chemistry Principles Towards The Sustainable Synthesis Of Biodiesel From Waste Vegetable Oil, Brandon Ackley
Research Brief: Applying Green Chemistry Principles Towards The Sustainable Synthesis Of Biodiesel From Waste Vegetable Oil, Brandon Ackley
Undergraduate Review
In 2011, the U.S. consumed over 18 million barrels per day of refined petroleum products and biofuels; almost 22% of global petroleum consumption. This includes oil used for transportation, electricity, and production of consumer products. More than half of this oil was imported from foreign countries, and in his 2006 State of the Union Address President Bush warned that, “We have a serious problem, America is addicted to oil, which is often imported from unstable parts of the world”. With the need for new energy sources more apparent than ever, serious research is needed to further the advancement of alternative …
Polymerase Manager Protein Umud Directly Regulates Escherichia Coli Dna Polymerase Iii Α Binding To Ssdna, Kathy R. Chaurasiya, Clarissa Ruslie, Michelle C. Silva, Lukas Voortman, Philip Nevin, Samer Lone, Penny J. Buening, Mark C. Williams
Polymerase Manager Protein Umud Directly Regulates Escherichia Coli Dna Polymerase Iii Α Binding To Ssdna, Kathy R. Chaurasiya, Clarissa Ruslie, Michelle C. Silva, Lukas Voortman, Philip Nevin, Samer Lone, Penny J. Buening, Mark C. Williams
Chemical Sciences Faculty Publications
Replication by Escherichia coli DNA polymerase III is disrupted on encountering DNA damage. Consequently, specialized Y-family DNA polymerases are used to bypass DNA damage. The protein UmuD is extensively involved in modulating cellular responses to DNA damage and may play a role in DNA polymerase exchange for damage tolerance. In the absence of DNA, UmuD interacts with the α subunit of DNA polymerase III at two distinct binding sites, one of which is adjacent to the single-stranded DNA-binding site of α. Here, we use single molecule DNA stretching experiments to demonstrate that UmuD specifically inhibits binding of α to ssDNA. …
Development Of Biomarkers For Endocrine Disrupting Compounds In The Fathead Minnow, Pimephales Promelas, Tara Frare
Development Of Biomarkers For Endocrine Disrupting Compounds In The Fathead Minnow, Pimephales Promelas, Tara Frare
Undergraduate Review
Organic waste compounds (OWC’s) are an environmental concern that can have adverse effects on humans, animals, and the environment. Ethinyl estradiol (EE2) is one common OWC and is an active ingredient in oral birth control pills. The presence of EE2 in aquatic environments and drinking water can be linked to decreased fertility and altered physiology in fish. I am developing Q-PCR biomarkers to detect changes in fish at low concentrations before adverse effects occur at higher concentrations. RNA was extracted from twenty fathead minnows that had not been exposed to OWC’s and will be used to synthesize cDNA. Thus far …
On The Perfection Of Broccoli: Talking To Ed Brush, Lee Torda
On The Perfection Of Broccoli: Talking To Ed Brush, Lee Torda
Bridgewater Review
No abstract provided.
Structure Of Human Dna Polymerase Κ Inserting Datp Opposite An 8-Oxog Dna Lesion, Rodrigo Vasquez-Del Carpio, Timothy D. Silverstein, Samer Lone, Michael K. Swan, Jayati R. Choudhury, Robert E. Johnson, Satya Prakash, Louise Prakash, Aneel K. Aggarwal
Structure Of Human Dna Polymerase Κ Inserting Datp Opposite An 8-Oxog Dna Lesion, Rodrigo Vasquez-Del Carpio, Timothy D. Silverstein, Samer Lone, Michael K. Swan, Jayati R. Choudhury, Robert E. Johnson, Satya Prakash, Louise Prakash, Aneel K. Aggarwal
Chemical Sciences Faculty Publications
Background: Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in DNA and 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the major lesions formed. It is amongst the most mutagenic lesions in cells because of its dual coding potential, wherein 8-oxoG(syn) can pair with an A in addition to normal base pairing of 8-oxoG(anti) with a C. Human DNA polymerase κ (Polκ) is a member of the newly discovered Y-family of DNA polymerases that possess the ability to replicate through DNA lesions. To understand the basis of Polκ's preference for insertion of an A opposite 8-oxoG lesion, …
Singing The Moly Blues: The Direct Use Of Molybdenum Clusters As A Precursor To The Development Of Molybdenum Blue Glazes, Margaret Fiedler
Singing The Moly Blues: The Direct Use Of Molybdenum Clusters As A Precursor To The Development Of Molybdenum Blue Glazes, Margaret Fiedler
Undergraduate Review
Cobalt is currently the most commonly used blue colorant for ceramic glazes, however due to its toxicity in powder form there is a need for an alternative. Molybdenum, more specifically molybdenum oxide, is one alternative that has shown promise. This research is aimed at the direct incorporation of reduced molybdenum clusters into the glaze matrix. Two compounds have been synthesized that exhibit an intense blue color, Na15[MoVI126MoV28O457H14(H2O)70]0.5-[MoVI124MoV28O427H14(H2O)68]0.5 …
Interactions Of Cis-Bis Ruthenium Complexes With Monosaccharides, Lindsay Mcdonald
Interactions Of Cis-Bis Ruthenium Complexes With Monosaccharides, Lindsay Mcdonald
Undergraduate Review
Molecular recognition and binding of oligosaccharides play an essential role in many biological processes including cell-cell recognition, signaling and adhesion. Our group is currently involved in the development of metal based receptors that can effectively bind specific glycoconjugates. Species that can selectively bind and chemically alter membrane glycoconjugates have the potential to inhibit tumor cell metastasis, inflammation and fibrosis. As an initial step towards our goal the interactions of cis-Ru(bpy)2(DMF)22+ (bpy = bipyridine, DMF = dimethylformamide) and cis-Ru(acac)2(CH3CN)2+ (acac = acetylacetonate) with the monosaccharides glucose and mannose have been examined …
Synthesizing And Characterizing Sr2Femoo6 Bulk And Thin Films, Louis Bianchini
Synthesizing And Characterizing Sr2Femoo6 Bulk And Thin Films, Louis Bianchini
Undergraduate Review
A Sr2FeMoO6 (SFMO) pellet was synthesized to use as a target in the Pulsed Laser Deposition (PLD) chamber. The method chosen was a solid state reaction of SrCO3, Fe2O3 and MoO3. All three materials were combined stoichiometrically, ground in a ball mixer, and annealed for 36 hours at 1000°C. A pellet press was custom designed and used to press the annealed powders into a pellet. The magnetic and structural properties of the powder were studied using a Quantum Design MPMS SQUID magnetometer and powder X-Ray diffractometer, respectively. Previous studies of …
Synthesis Of Phenoxides With Pendant Amines And Catalytic Intramolecular Hydroaminations, Kenneth Awasung
Synthesis Of Phenoxides With Pendant Amines And Catalytic Intramolecular Hydroaminations, Kenneth Awasung
Undergraduate Review
One core focus of my research project, (my 2007 summer research) is to make structural analogs of substituted phenols to support the titanium catalysis of organic compounds. The synthesis and study of these and related ligands, (pyrrolyls, aldimines, salens, and other nitrogen/oxygen heterocycles) is a major field of organometallic chemistry. Bulky phenols and their analogs serve as highly effective ligands to support catalysis due to their sterics and electronics. I have been designing and have begun synthesizing phenol analogs using a series of aldol condensations and michael additions and other organic chemistry methodology to generate new substituted phenols. Our method …
Surge Of Green: A Sustainable Approach To Conductive Polymers, Bethany Masten
Surge Of Green: A Sustainable Approach To Conductive Polymers, Bethany Masten
Undergraduate Review
No abstract provided.
Hydromination Of Alkynes, Enynes, And Dienes Using Titanium Catalysts, Taryn Palluccio
Hydromination Of Alkynes, Enynes, And Dienes Using Titanium Catalysts, Taryn Palluccio
Undergraduate Review
No abstract provided.
Development Of Dirhodium Sugar-Substituted Carboxylate And Acetamide Complexes And Evaluation Of Their Potential As Lectin Inhibitors, Bethany Masten
Development Of Dirhodium Sugar-Substituted Carboxylate And Acetamide Complexes And Evaluation Of Their Potential As Lectin Inhibitors, Bethany Masten
Undergraduate Review
No abstract provided.
The Chemistry Of Allergies, Henry Daley
The Thirsty Earth: Acid Rain - A Sour Drink, Margaret R. Souza
The Thirsty Earth: Acid Rain - A Sour Drink, Margaret R. Souza
Bridgewater Review
No abstract provided.