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Physical Sciences and Mathematics Commons™
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Articles 1 - 7 of 7
Full-Text Articles in Physical Sciences and Mathematics
Characterization Of Dimerization Domains On The Mannose-6-Phosphate/Insulin-Like Growth Factor 2 Receptor, Tyler Degener
Characterization Of Dimerization Domains On The Mannose-6-Phosphate/Insulin-Like Growth Factor 2 Receptor, Tyler Degener
UNO Student Research and Creative Activity Fair
The mannose-6-phosphate/insulin-like growth factor 2 (M6P/IGF2) receptor is a transmembrane protein with the ability to sequester growth factors from the extracellular matrix. This behavior links the receptor to tumor suppression. On a structural level, the extracellular portion of the protein is segmented into 15 homologous repeats, which can be divided further into 5 triplet domains, labelled 1-3, 4-6, 7-9, 10-12, and 13-15. Each triplet receptor displays its own unique ligand binding affinity, including the ability to form dimers with triplets on a second M6P/IGF2 receptor. In fact, previous studies indicate that this protein functions optimally when dimerized. Thus, the purpose …
Design, Construction, And Characterization Of A Low-Cost Spectrometer With Interchangeable Parts, Jack Godek
Design, Construction, And Characterization Of A Low-Cost Spectrometer With Interchangeable Parts, Jack Godek
UNO Student Research and Creative Activity Fair
A low-cost spectrometer was designed for the purpose of teaching spectroscopy. The spectrometer can be built by the student and contains interchangeable pieces such as slit width, grating, and lenses. This will allow the student to understand how changing these variables effects resolution. The spectrometer was constructed from PVC pipe, a plastic electrical box, and a USB webcam. The actual resolution of the spectrometer is close to the theoretical value, depending on which lens and grating is used. In addition, an extra piece can be added that allows absorption spectra to be collected. Having the student piece together the spectrometer …
Lake Sediment Analysis At Heron Haven Nature Center, Erik Lato
Lake Sediment Analysis At Heron Haven Nature Center, Erik Lato
UNO Student Research and Creative Activity Fair
Understanding the chemical composition of a wetland sanctuary lakebed can help us understand how recent developments may have changed the chemical composition. Due to recent dredging by the U.S. Army Corps of Engineers and previous research on water composition at Heron Haven, the goal of this project was to determine the chemical composition as a function of sediment depth. The concentration of seven different metals and nutrients were analyzed in terms of depth. The aluminum, iron, and phosphate concentrations had no real discernible concentration change as a function of depth. There is some hint of a steady increase of manganese …
Investigating Daily Variation In Lotic Prairie Ecosystems, Dominick Caniglia
Investigating Daily Variation In Lotic Prairie Ecosystems, Dominick Caniglia
UNO Student Research and Creative Activity Fair
The goal of this project is to investigate the hydrochemistry of the prairie stream system at Glacier Creek Preserve, namely to determine the chemical behavior as it varies over time. Past sampling revealed annual/seasonal trends, which prompted this study investigating possible changes over the course of a day. To accomplish this, water samples were taken hourly for a twelve hour period in September and November 2018, and were analyzed at the Durham Science Center. All samples were obtained at the furthest downstream site available. The main focus was to study alkalinity and dissolved mineral content. Preliminary data suggests that alkalinity …
Synthesis Of A Sulfur Variant For Treatment Of Trypanosomiasis, Carlos Vera-Esquivel
Synthesis Of A Sulfur Variant For Treatment Of Trypanosomiasis, Carlos Vera-Esquivel
UNO Student Research and Creative Activity Fair
Previous work in our lab has found diphenyl ether benzylamines showed a successful response with a micromolar concentration of our lead compound to treat the deadly Trypanosamiosis rhodesience. Furthermore, mammalian cell lines saw promising resistance towards damages. The goal of this study was to synthesize a diphenyl thio benzylamine variant. This variant was more active toward T. b. rhodesience but showed more toxicity to both rat 10 (IC50 mM) and human cell lines (HFF, HC-04, U-2 OS, and HEK293). The selectivity index (ratio of toxicity to activity in the same concentration units (SI)) …
Supercell Crystal Structure Of Na2ga2(Bo3)2, Grace Brown
Supercell Crystal Structure Of Na2ga2(Bo3)2, Grace Brown
UNO Student Research and Creative Activity Fair
Na2Ga2(BO3)2O is an oxyborate with a reported crystal structure in the trigonal space group P1c. The literature states that the three-dimensional structure is created from infinite stacking of parallel [NaGa2(BO3)2] ∞ sheets separated by sodium layers. Our single-crystal X-ray diffraction data requires some modification to this structure. We believe that Na2Ga2(BO3)2O actually possesses a supercell crystal structure with lower symmetry. The borate anions within the [NaGa2(BO3)2 ] sheets are not parallel to each …
Characterization Of The Mannose-6-Phosphate/Insulin-Like Growth Factor Ii Receptor Using 1-3mh, Zechariah Craig
Characterization Of The Mannose-6-Phosphate/Insulin-Like Growth Factor Ii Receptor Using 1-3mh, Zechariah Craig
UNO Student Research and Creative Activity Fair
The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), a recombinant triplet protein receptor for studies involving receptor dimerization, plays a pivotal role in mediating cellular growth. This receptor is comprised of fifteen similar units that fold into five triplet subunits. The goal of this experiment is to investigate how to make the 1-3MH protein more stable at the DNA level and generate a larger yield from DNA extractions for more effective transfections. This was accomplished by minorly changing the protocols for the DNA purification. Instead of using a standard column DNA purification kit, a crude DNA purification was done instead. This …