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Full-Text Articles in Physical Sciences and Mathematics
Kinetic And Mechanistic Studies Of The Deuterium Exchange In Classical Keto−Enol Tautomeric Equilibrium Reactions, Michael Nichols, Mark Waner
Kinetic And Mechanistic Studies Of The Deuterium Exchange In Classical Keto−Enol Tautomeric Equilibrium Reactions, Michael Nichols, Mark Waner
Mark J. Waner
An extension of the classic keto−enol tautomerization of β-dicarbonyl compounds into a kinetic analysis of deuterium exchange is presented. It is shown that acetylacetone and ethyl acetoacetate undergo nearly complete deuterium exchange of the α-methylene carbon when dissolved in methanol-d4. The extent of deuteration may be monitored via NMR spectroscopy as a function of time. A mechanism for deuterium exchange is presented and shown to be consistent with a consecutive first-order process. The data for acetylacetone are consistent with steady-state kinetics, whereas those of ethyl acetoacetate illustrate nonsteady-state behavior, offering an accessible example where students might collect and analyze real …
Kinetic And Mechanistic Studies Of The Deuterium Exchange In Classical Keto−Enol Tautomeric Equilibrium Reactions, Michael Nichols, Mark Waner
Kinetic And Mechanistic Studies Of The Deuterium Exchange In Classical Keto−Enol Tautomeric Equilibrium Reactions, Michael Nichols, Mark Waner
Michael A Nichols
An extension of the classic keto−enol tautomerization of β-dicarbonyl compounds into a kinetic analysis of deuterium exchange is presented. It is shown that acetylacetone and ethyl acetoacetate undergo nearly complete deuterium exchange of the α-methylene carbon when dissolved in methanol-d4. The extent of deuteration may be monitored via NMR spectroscopy as a function of time. A mechanism for deuterium exchange is presented and shown to be consistent with a consecutive first-order process. The data for acetylacetone are consistent with steady-state kinetics, whereas those of ethyl acetoacetate illustrate nonsteady-state behavior, offering an accessible example where students might collect and analyze real …
Structural Characterization Of Mixed Alkali Metal Bis(Trimethylsilyl)Amide Bases., Paul Williard, Michael Nichols
Structural Characterization Of Mixed Alkali Metal Bis(Trimethylsilyl)Amide Bases., Paul Williard, Michael Nichols
Michael A Nichols
No abstract provided.
Chelation Of 2-Substituted 1-Lithoxides: Structural And Energetic Factors Of Relevance To Synthetic Organic Chemistry., Michael Nichols, Andrew Mcphail, Edward Arnett
Chelation Of 2-Substituted 1-Lithoxides: Structural And Energetic Factors Of Relevance To Synthetic Organic Chemistry., Michael Nichols, Andrew Mcphail, Edward Arnett
Michael A Nichols
No abstract provided.
Structural And Energetic Evidence For Oxygen-Lithium-Nitrogen Chelation In A Model For Asymmetric Induction., Edward Arnett, Michael Nichols, Andrew Mcphail
Structural And Energetic Evidence For Oxygen-Lithium-Nitrogen Chelation In A Model For Asymmetric Induction., Edward Arnett, Michael Nichols, Andrew Mcphail
Michael A Nichols
No abstract provided.
Structure-Energy Relations For The Aldol Reaction In Nonpolar Media., Edward Arnett, Franklin Fisher, Michael Nichols, Anthony Ribeiro
Structure-Energy Relations For The Aldol Reaction In Nonpolar Media., Edward Arnett, Franklin Fisher, Michael Nichols, Anthony Ribeiro
Michael A Nichols
No abstract provided.
Thermochemistry Of A Structurally Defined Aldol Reaction., Edward Arnett, Franklin Fisher, Michael Nichols, Anthony Ribeiro
Thermochemistry Of A Structurally Defined Aldol Reaction., Edward Arnett, Franklin Fisher, Michael Nichols, Anthony Ribeiro
Michael A Nichols
No abstract provided.