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Full-Text Articles in Physical Sciences and Mathematics
Development Of A Rapid Spme/Gc-Ms Method For The Detection And Quantification Of Synthetic Cathinones In Oral Fluid, David Correll
Development Of A Rapid Spme/Gc-Ms Method For The Detection And Quantification Of Synthetic Cathinones In Oral Fluid, David Correll
Senior Theses and Projects
The recent emergence and widespread abuse of new classes of compounds on the designer drug market as “legal” alternatives to scheduled drugs such as Ecstasy has prompted interest in the development of analytical methods for their detection and characterization. Synthetic cathinones, which are structurally similar to amphetamines, are commonly advertised as a “legal highs” or “herbal highs,” and are marketed under names such as “bath salts” and “plant food.” To avoid drug abuse legislation, a “not for human consumption” warning is typically printed on the label. Their ready availability on the Internet and in “head” shops, convenience stores, and even …
Ferrocene Constrained Helical Peptides Via On-Resin Cyclization, Thomas A. Mcteague
Ferrocene Constrained Helical Peptides Via On-Resin Cyclization, Thomas A. Mcteague
Senior Theses and Projects
Previous research within the Curran group has demonstrated that ferrocene may be used as an organometallic constraint to induce the formation of α-helices in short peptides which traditionally possess undefined conformations. Through strategic placement of lysine residues at the i and i+3 positions within the peptide, such a constraint was accomplished via the crosslinking of the lysine side chains to ferrocene dicarboxylic acid chloride in solution phase synthesis. The aim of this work was to develop a method for solid phase peptide synthesis (SPPS) for the synthesis of these ferrocene-constrained helices. In particular, we seek to develop a method in …