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Biotechnology

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Full-Text Articles in Physical Sciences and Mathematics

Modelling And Parameter Identification For A Nonlinear Time-Delay System In Microbial Batch Fermentation, Chongyang Liu Dec 2012

Modelling And Parameter Identification For A Nonlinear Time-Delay System In Microbial Batch Fermentation, Chongyang Liu

Chongyang Liu

Mathematical modelling and parameter identification of a microbial batch fermentation process is considered in this paper. In view of the existence of time delays, a nonlinear time-delay system is firstly proposed to formulate the fermentation process. Some important properties are also discussed. Taking the errors between the computational values and the experimental data as the cost function, a parameter identification model subject to continuous state constraints and parameter constraints is then presented. To seek the optimal time delay and the optimal kinetic parameters, an improved differential evolution algorithm in conjunction with the constraint transcription technique is developed. Finally, numerical results …


Optimal Switching Control For Microbial Fed-Batch Culture, Chongyang Liu, Zhaohua Gong, Enmin Feng, Hongchao Yin Jan 2008

Optimal Switching Control For Microbial Fed-Batch Culture, Chongyang Liu, Zhaohua Gong, Enmin Feng, Hongchao Yin

Chongyang Liu

In fed-batch culture of glycerol bio-dissimilation to 1,3-propanediol (1,3-PD), the aim of adding glycerol is to obtain as much 1,3-PD as possible. Hence, a proper feed strategy is required during the process. In this paper, we present an optimal switching control model based on our proposed controlled switching system. Some properties of the controlled switching system are obtained. Subsequently, we prove the existence of optimal control. In order to deduce the optimality conditions, we transcribe the optimal switching control model into an equivalent one with fixed switching instants and parameters. Finally, the optimality conditions of the equivalent problem are investigated …