Open Access. Powered by Scholars. Published by Universities.®

Physical Sciences and Mathematics Commons™

Open Access. Powered by Scholars. Published by Universities.®

Biotechnology

David D Nolte

Selected Works

Articles 1 - 2 of 2

Full-Text Articles in Physical Sciences and Mathematics

Table Of Contents, David D. Nolte Dec 2010

Table Of Contents, David D. Nolte

David D Nolte


Light is at once the most sensitive and the most gentle probe of matter.  It is commonplace for light to measure a picometer displacement far below the nanometer scale of atoms, or to capture the emission of a single photon from a fluorescent dye molecule.  Light is easy to generate using light-emitting diodes or lasers, and to detect using ultrasensitive photodetectors as well as the now ubiquitous digital cameras.  Light also has the uncanny ability to penetrate living tissue harmlessly and deeply, while capturing valuable information on the health and function of cells.  For these reasons, light has become an …

Go to article

Review Of Biocd Physics And Technology, David D. Nolte Dec 2008

Review Of Biocd Physics And Technology, David D. Nolte

David D Nolte

Spinning biodisks have advantages that make them attractive for specialized biochip applications. The two main classes of spinning biodisks are microfluidic disks and bio-optical compact disks BioCD. Microfluidic biodisks take advantage of noninertial pumping for lab-on-a-chip devices using noninertial valves and switches under centrifugal and Coriolis forces to distribute fluids about the disks. BioCDs use spinning-disk interferometry, under the condition of common-path phase quadrature, to perform interferometric label-free detection of molecular recognition and binding. The optical detection of bound molecules on a disk is facilitated by rapid spinning that enables high-speed repetitive sampling to eliminate 1/ f noise through common-mode …

Go to article