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Full-Text Articles in Physical Sciences and Mathematics
Stage-Specific Predictive Models For Cancer Survivability, Elham Sagheb Hossein Pour
Stage-Specific Predictive Models For Cancer Survivability, Elham Sagheb Hossein Pour
Theses and Dissertations
Survivability of cancer strongly depends on the stage of cancer. In most previous works, machine learning survivability prediction models for a particular cancer, were trained and evaluated together on all stages of the cancer. In this work, we trained and evaluated survivability prediction models for five major cancers, together on all stages and separately for every stage. We named these models joint and stage-specific models respectively. The obtained results for the cancers which we investigated reveal that, the best model to predict the survivability of the cancer for one specific stage is the model which is specifically built for that …
Detecting Association Of Gene-Environment Interactions In Common And Rare Variants For Hypertension, Miguelangel Diaz Medina
Detecting Association Of Gene-Environment Interactions In Common And Rare Variants For Hypertension, Miguelangel Diaz Medina
Theses and Dissertations
Subsequent malignant neoplasms (SMNs) or secondary cancers are one of the most negative effects resulting from cancer treatment such as chemotherapy or radiation. Given the severity and high incidence of mortality faced by cancer survivors, it is critical that we understand the cause of SMNs so that preventive measures or intervention can be done for individuals facing a higher risk of SMN incidence. The purpose of this thesis is to test the efficacy of newly developed statistical methods used to identify gene-environment interactions that are associated with a specific disease, in this case, SMNs, considering both common and rare variants, …
Are We Missing The Forest For The Trees? Quantifying The Maintenance Of Diversity In Temperate Deciduous Forests, Kathryn Barry
Are We Missing The Forest For The Trees? Quantifying The Maintenance Of Diversity In Temperate Deciduous Forests, Kathryn Barry
Theses and Dissertations
One of the most pressing questions of community ecology is: Why do we have so many species? Over 100 hypotheses have been proposed to answer this question for woody plants over the past 70 years, yet there remains no consensus among community ecologists. In this dissertation, I explore the evidence supporting several different hypotheses (Chapter 1). I provide evidence that negative density dependence, where individuals perform poorly near members of their own species, may only be relevant for canopy tree species (Chapter 2). Understory species do not demonstrate negative density dependence while canopy trees demonstrate negative density dependence that increases …