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Sample Size Calculation For Ph Mixture Cure Model, Yihong Zhan

Theses and Dissertations

With the development of advanced medical technology, a significant proportion of patients can be cured of many chronic diseases. Because a substantial fraction of patients have censored information, the standard survival model, such as the proportional hazards (PH) model cannot capture the cured information of patients. Thus PH mixture cure model is developed to handle the survival data with potential cured information. A corresponding sample size formula based on log rank test has been proposed by Wang et al. (2012) and the probability of death in their formula is only contributed by the control arm. However, to calculate the sample …