Physical Sciences and Mathematics Commons^™

Differentially Expressed Genes In Blood From Young Pigs Between Two Swine Lines Divergently Selected For Feed Efficiency: Potential Biomarkers For Improving Feed Efficiency, Haibo Liu, Yet T. Nguyen, Daniel S. Nettleton, Jack C. M. Dekkers, Christopher K. Tuggle

Dan Nettleton

The goal of this study was to find potential gene expression biomarkers in blood of piglets that can be used to predict pigs’ future feed efficiency. Using RNA-seq technology, we found 453 genes were differentially expressed (false discovery rate (FDR) ≤ 0.05) in the blood of two Yorkshire lines of pigs divergently selected for feed efficiency (FE) based on residual feed intake (RFI). Genes involved in several biosynthetic processes were overrepresented among genes more highly expressed in the low RFI line compared to the high RFI line. Weighted gene co-expression network analysis (WGCNA) also revealed genes involved in some of …

Corn-Soybean And Alternative Cropping Systems Effects On No 3 -N Leaching Losses In Subsurface Drainage Water, Rameshwar S. Kanwar, Richard M. Cruse, Mohammadreza Ghaffarzadeh, Allah Bakhsh, Douglas Karlen, Theodore B. Bailey

Douglas L Karlen

Alternative cropping systems can improve resource use efficiency, increase corn grain yield, and help in reducing negative impacts on the environment. A 6-yr (1993 to 1998) field study was conducted at the Iowa State University’s Northeastern Research Center near Nashua, Iowa, to evaluate the effects of non-traditional cropping systems [strip inter cropping (STR)-corn (Zea mays L.)/soybean (Glycine max L.)/oats (Avina sativa L.)]; alfalfa rotation (ROT)-3-yr (1993 to 1995) alfalfa (Medicago sativa L.) followed by corn in 1996, soybean in 1997, and oats in 1998), and traditional cropping system (corn after soybean (CS) and soybean after corn (SC) on the flow …

Cropping System Effects On No3-N Loss With Subsurface Drainage Water, Allah Bakhsh, Rameshwar S. Kanwar, Theodore B. Bailey, Cynthia A. Cambardella, Douglas Karlen, Thomas S. Colvin

Douglas L Karlen

An appropriate combination of tillage and nitrogen management practices will be necessary to develop sustainable farming practices. A six–year (1993–1998) field study was conducted on subsurface–drained Clyde–Kenyon–Floyd soils to quantify the impact of two tillage systems (chisel plow vs. no tillage) and two N fertilizer management practices (preplant single application vs. late–spring soil test based application) on nitrate–nitrogen (NO3–N) leaching loss with subsurface drain discharge from corn (Zea mays L.) soybean (Glycine max L.) rotation plots. Preplant injected urea ammonium nitrate solution (UAN) fertilizer was applied at the rate of 110 kg ha–1 to chisel plow and no–till corn plots, …

National Estimates Of The Prevalence Of Alzheimer's Disease In The United States, Ron Brookmeyer, Denis Evans, Liesi Hebert, Langa Kenneth, Heeringa Steven, Plassman Brenda, Kukull Kenneth

Ron Brookmeyer

Several methods of estimating prevalence of dementia are presented in this article. For both Brookmeyer and the Chicago Health and Aging project (CHAP), the estimates of prevalence are derived statistically, forward calculating from incidence and survival figures. The choice of incidence rates on which to build the estimates may be critical. Brookmeyer used incidence rates from several published studies, whereas the CHAP investigators applied the incidence rates observed in their own cohort. The Aging, Demographics, and Memory Study (ADAMS) and the East Boston Senior Health Project (EBSHP) were sample surveys designed to ascertain the prevalence of Alzheimer’s disease and dementia. …

On The Statistical Accuracy Of Biomarker Assays Of Hiv Incidence, Ron Brookmeyer

Ron Brookmeyer

Objective: To evaluate the statistical accuracy of estimates of current HIV incidence rates from cross-sectional surveys, and to identify characteristics of assays that improve accuracy.

Methods: Performed mathematical and statistical analysis of the cross-sectional estimator of HIV incidence to evaluate bias and variance. Developed probability models to evaluate impact of long tails of the window period distribution on accuracy.

Results: The standard cross-sectional estimate of HIV incidence rate is estimating a time-lagged incidence where the lag time, called the shadow, depends on the mean and the coefficient of variation of window periods. Equations show how the shadow increases with the …