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Bayes factors; Clearance; Compartmental Models; Non-Linear Mixed Effects Models; Rejection algorithm
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Gamma Generalized Linear Models For Pharmacokinetic Data, Ruth Salway, Jon Wakefield
Gamma Generalized Linear Models For Pharmacokinetic Data, Ruth Salway, Jon Wakefield
UW Biostatistics Working Paper Series
This paper considers the modeling of single dose pharmacoki- netic data. Traditionally, so-called compartmental models have been used to analyze such data. Unfortunately the mean function of such models are sums of exponentials for which inference and computation may not be straightfor- ward. We present an alternative to these models based on generalized linear models, for which desirable statistical properties exist, with a logarithmic link and gamma distribution. The latter has a constant coefficient of variation which is often appropriate for pharmacokinetic data. Inference is convenient from either a likelihood or a Bayesian perspective. We consider models for both single …