Physical Sciences and Mathematics Commons^™

Transcriptional Dynamics During Rhodococcus Erythropolis Infection With Phage Wc1, Dana Willner, Sudip Paudel, Andrew D. Halleran, Grace E. Solini, Veronica Gray, Margaret Saha

Arts & Sciences Articles

Background

Belonging to the Actinobacteria phylum, members of the Rhodococcus genus thrive in soil, water, and even intracellularly. While most species are non-pathogenic, several cause respiratory disease in animals and, more rarely, in humans. Over 100 phages that infect Rhodococcus species have been isolated but despite their importance for Rhodococcus ecology and biotechnology applications, little is known regarding the molecular genetic interactions between phage and host during infection. To address this need, we report RNA-Seq analysis of a novel Rhodococcus erythopolis phage, WC1, analyzing both the phage and host transcriptome at various stages throughout the infection process.

Results

By five …

Population Genetics Of Transposable Element Load: A Mechanistic Account Of Observed Overdispersion, Gregory Conradi Smith, Ron D. Smith, Joshua Puzey

Arts & Sciences Articles

In an empirical analysis of transposable element (TE) abundance within natural populations of Mimulus guttatus and Drosophila melanogaster, we found a surprisingly high variance of TE count (e.g., variance-to-mean ratio on the order of 10 to 300). To obtain insight regarding the evolutionary genetic mechanisms that underlie the overdispersed population distributions of TE abundance, we developed a mathematical model of TE population genetics that includes the dynamics of element proliferation and purifying selection on TE load. The modeling approach begins with a master equation for a birth-death process and extends the predictions of the classical theory of TE dynamics in …

Living Shorelines Achieve Functional Equivalence To Natural Fringe Marshes Across Multiple Ecological Metrics, Robert Isdell, Donna M. Bilkovic, Amanda Guthrie, Molly Mitchell, Randolph M. Chambers, Matthias Leu, Carl Hershner

VIMS Articles

Nature-based shoreline protection provides a welcome class of adaptations to promote ecological resilience in the face of climate change. Along coastlines, living shorelines are among the preferred adaptation strategies to both reduce erosion and provide ecological functions. As an alternative to shoreline armoring, living shorelines are viewed favorably among coastal managers and some private property owners, but they have yet to undergo a thorough examination of how their levels of ecosystem functions compare to their closest natural counterpart: fringing marshes. Here, we provide a synthesis of results from a multi-year, large-spatial-scale study in which we compared numerous ecological metrics (including …

Allostery In Oligomeric Receptor Models, Gregory D. Conradi Smith

Arts & Sciences Articles

We show how equilibrium binding curves of receptor homodimers can be expressed as rational polynomial functions of the equilibrium binding curves of the constituent monomers, without approximation and without assuming independence of receptor monomers. Using a distinguished spanning tree construction for reduced graph powers, the method properly accounts for thermodynamic constraints and allosteric interactions between receptor monomers (i.e. conformational coupling). The method is completely general; it begins with an arbitrary undirected graph representing the topology of a monomer state-transition diagram and ends with an algebraic expression for the equilibrium binding curve of a receptor oligomer composed of two or more …

One Fish, Two Fish, Red Fish, Whose Fish? Subjects: Life Science, Environmental Science, Marine / Ocean Science, Shelby White

Reports

This activity invites students to assume the role of various stakeholders in fisheries management and actively discuss the influence of economics, ecology and human interactions in decision-making.

Students will demonstrate their argument for/against a certain regulation by participating as a specific stakeholder (i.e. commercial fisher, recreational fisher, scientists/researcher, environmental group, management agency, and citizen). Students will recognize that stakeholders tend to advocate based on their individual needs, often making it difficult for proposed policies to satisfy the needs of all stakeholders and achieve sustainability goals.

Expedition Sediments: Mud's Journey Through The Watershed. Subjects: Earth Science / Environmental Science Grades: 9-12, Jessie Turner

Reports

Expedition Sediments is a game-in-a-lesson that allows students to explore the movement of sediments through watersheds by moving around the classroom. This lesson explores how grains of estuarine mud and sand move throughout estuaries and coastal regions, with a focus on processes surrounding a highly populated estuary such as the Chesapeake Bay. By the end of the lesson, students will be able to explain how sediments are transported through an estuary, graph sediment residence times in different locations, and compare the timescales of different sediment transport processes.

Oscillation Regularity In Noise-Driven Excitable Systems With Multi-Time-Scale Adaptation, William H. Nesse, Christopher A. Del Negro, Paul C. Bressloff

Arts & Sciences Articles

We investigate oscillation regularity of a noise-driven system modeled with a slow after-hyperpolarizing adaptation current (AHP) composed of multiple-exponential relaxation time scales. Sufficiently separated slow and fast AHP time scales (biphasic decay) cause a peak in oscillation irregularity for intermediate input currents I, with relatively regular oscillations for small and large currents. An analytic formulation of the system as a stochastic escape problem establishes that the phenomena is distinct from standard forms of coherence resonance. Our results explain data on the oscillation regularity of the pre-Bötzinger complex, a neural oscillator responsible for inspiratory breathing rhythm generation in mammals.

Bahamas Bibliography : A List Of Citations For Scientific, Engineering And Historical Articles Pertaining To The Bahama Islands, Carol Fang, W. Harrison

Reports

Specialized bibliographies are sometimes needed in connection with the research studies being pursued at the Virginia Institute of Marine Science. The Bahamas Bibliography arose out of the needs of marine geologists, biologists and physical oceanographers engaged in studies of beaches, fishes and inlet currents in the Bahama Islands. Although the present bibliography may suffer from completeness, it significantly surpasses in number of citations the only other known bibliography of like kind.