Physical Sciences and Mathematics Commons^™

Unraveling Plague Ecology Through Vector And Host Genetics, Rachael Marie Giglio

Theses and Dissertations

The transmission of vector-borne diseases involves complex interactions between vectors and their host species. These complex host-parasite interactions can be difficult to study with traditional, field-based methods. My dissertation aims to use a population genomics approach to elucidate transmission pathways of plague among prairie dog colonies. Plague is a flea-borne, zoonotic disease caused by the bacterium Yersinia pestis. It is infamous for causing the Black Death (1347-1353), one of the most devastating pandemics in human history. Since its emergence in North America around 1900, plague has spread to native rodents, thus creating a sylvatic cycle. Prairie dogs (Cynomys spp.) are …