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Full-Text Articles in Physical Sciences and Mathematics
Eye Lens Β-Crystallins Are Predicted By Native Ion Mobility-Mass Spectrometry And Computations To Form Compact Higher-Ordered Heterooligomers, Amber D. Rolland, Takumi Takata, Micah T. Donor, Kirsten J. Lampi, James S. Prell
Eye Lens Β-Crystallins Are Predicted By Native Ion Mobility-Mass Spectrometry And Computations To Form Compact Higher-Ordered Heterooligomers, Amber D. Rolland, Takumi Takata, Micah T. Donor, Kirsten J. Lampi, James S. Prell
Faculty Publications - Department of Biological & Molecular Science
Eye lens crystallin proteins maintain the refractive properties of the lens but are not replaced after denucleation. Rolland et al. use native ion mobility-mass spectrometry, kinetics experiments, and computations to reveal that b-crystallins form heterodimers. These likely assemble into compact heterooligomers that enable the very high protein concentrations found in lens tissue.