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Full-Text Articles in Physical Sciences and Mathematics
Relation Prediction Over Biomedical Knowledge Bases For Drug Repositioning, Mehmet Bakal
Relation Prediction Over Biomedical Knowledge Bases For Drug Repositioning, Mehmet Bakal
Theses and Dissertations--Computer Science
Identifying new potential treatment options for medical conditions that cause human disease burden is a central task of biomedical research. Since all candidate drugs cannot be tested with animal and clinical trials, in vitro approaches are first attempted to identify promising candidates. Likewise, identifying other essential relations (e.g., causation, prevention) between biomedical entities is also critical to understand biomedical processes. Hence, it is crucial to develop automated relation prediction systems that can yield plausible biomedical relations to expedite the discovery process. In this dissertation, we demonstrate three approaches to predict treatment relations between biomedical entities for the drug repositioning task …
Scalable Feature Selection And Extraction With Applications In Kinase Polypharmacology, Derek Jones
Scalable Feature Selection And Extraction With Applications In Kinase Polypharmacology, Derek Jones
Theses and Dissertations--Computer Science
In order to reduce the time associated with and the costs of drug discovery, machine learning is being used to automate much of the work in this process. However the size and complex nature of molecular data makes the application of machine learning especially challenging. Much work must go into the process of engineering features that are then used to train machine learning models, costing considerable amounts of time and requiring the knowledge of domain experts to be most effective. The purpose of this work is to demonstrate data driven approaches to perform the feature selection and extraction steps in …