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Development Of Peptide Inhibitors Targeting Clostridium Difficile Toxins A/B And Characterizing The Regulatory Role Of A Putative Negative Regulator Tcdc In Clostridium Difficile Toxin Gene Expression, Sanofar Jainul Abdeen
Development Of Peptide Inhibitors Targeting Clostridium Difficile Toxins A/B And Characterizing The Regulatory Role Of A Putative Negative Regulator Tcdc In Clostridium Difficile Toxin Gene Expression, Sanofar Jainul Abdeen
Wayne State University Dissertations
Clostridium difficile infections cause one of the most common and vital hospitalacquired
diseases often associated with broad-spectrum antibiotic usage. TcdA and TcdB
are the key virulence factors involved in major patho-physiology. While standard
antibiotics provide some respite, due to the high relapse rates and the emergence of more
severe disease presentations, antibiotics alone have often proven to be suboptimal.
Therefore there is a desperate need to develop an effective non-antimicrobial
therapeutics. Part of this work focuses on identification and further characterization of
peptide therapeutic that target the major virulence factor TcdA/TcdB. Towards
development of mechanistic-based anti-toxin agent, phage display was …