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Investigation Of Catalysis Of Nitration By Cytochrome P450s, Lannika Johnson
Investigation Of Catalysis Of Nitration By Cytochrome P450s, Lannika Johnson
Honors Undergraduate Theses
TxtE is a protein related to cytochrome P450 enzymes, which catalyze a number of reactions that typically involve oxygen and not nitrogen. It has been discovered that TxtE can nitrate tryptophan through an unusual reaction in which it uses nitric oxide (NO) as a nitrogen donor to install the nitro group despite NO typically being considered toxic to bacteria. This project will determine if all cytochromes P450 can catalyze nitration as long as they are given NO. This will have an impact on understanding drug delivery and metabolism for which nitration is important.
Investigation Of Dna Hybridization In Localized Systems In Close Proximity, Ashley M. Sewsankar
Investigation Of Dna Hybridization In Localized Systems In Close Proximity, Ashley M. Sewsankar
Honors Undergraduate Theses
Hybridization of two or more DNA or RNA strands is well documented for the process taking place with all strands free in solution or when one strand is immobilized on a substrate. This study contributes to the investigation of the hybridization process when two single DNA strands (ssDNA) are in close proximity. We took advantage of an X sensor in which hybridization of four DNA strands enables the formation of a DNA four-way junction (crossover or X) structure. We immobilized multiple layers of crossover structures to study its hybridization being triggered by short ssDNA coming from solution and further investigate …