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Full-Text Articles in Physical Sciences and Mathematics
O-Glcnac Post Translational Modification Of Hypoxia-Inducible Factor (Hif) Proteins, Hailey Elisabeth Grisham
O-Glcnac Post Translational Modification Of Hypoxia-Inducible Factor (Hif) Proteins, Hailey Elisabeth Grisham
Honors Theses
O-linked β-N-acetylglucosamine (O-GlcNAc) post-translational modification (O- GlcNAcylation), plays a vital role in many metabolic pathways, including those of numerous diseases. New research methods and basic functional roles of O-GlcNAc post- translational modification on metabolism, human health, and cancer are quickly developing, but a vast amount of research remains on the specificity of this pathway towards specific proteins. In this study, T47D breast cancer cells were used as an in vitro model to investigate the effects of O-GlcNAc modification on hypoxia-inducible factor (HIF) proteins.
Targeting Metastatic Breast Cancer With Statin Drugs And Coq10, Jacob Thrasher
Targeting Metastatic Breast Cancer With Statin Drugs And Coq10, Jacob Thrasher
Honors Theses
Statin drugs are commonly prescribed to lower cholesterol levels in patients, but recently statins have been under investigation as a potential anti-cancer drug. Statins are HMG-CoA reductase inhibitors and subsequently inhibit the mevalonate pathway and cholesterol synthesis. Since cholesterol trafficking is vital in the growth and metastasis of cancer, statin drugs are being studied to explore their effects on cancer cells. CoQ10, one of the products from the mevalonate pathway, also has shown some potential anti-cancer properties, but its use to combat cancer is controversial. While some studies have shown that CoQ10 supplements can be synergistic with other cancer treatment …